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Diss Factsheets
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EC number: 215-607-8 | CAS number: 1333-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds: reproduction test
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
From EU RAR (2005):
Chromium (VI) has been shown to be taken up by a wide range of organisms
from water, sediment and soil. For fish, although uptake does occur, the
bioconcentration factors for chromium (VI) are usually very low (~1
l/kg).
The toxicity of chromium (VI) to birds has been studied by several
authors. Biswas (1985) reported an 18 day-LD50 value for chromium (VI)
(as potassium dichromate) of 300 ppm for chick embryos. In the
experiment, embryonated eggs were inoculated with solutions of potassium
dichromate and it is not clear from the paper if the LD50 refers to the
concentration of chromium in the solution given to the eggs or to the
dose of chromium given to the eggs. Huu Chanh and Chanvatte (1967)
investigated the toxicity of chromium (VI) (as sodium chromate) to
pigeon (Columba domestica)and chicken (Gallus gallus), by
intravenous injection of solutions of the chemical. The 60-minute lethal
dose was found to be 101.9-111.3 mg/kg body weight for pigeon and
105.4-107.6 mg/kg body weight for chicken.
The toxicity of chromium (VI) (as sodium chromate) has been studied in a
1-year feeding study using chickens (Gallus gallus). In the
study, the chickens were fed parboiled rice containing 0.7 mg Cr/kg
rice. The estimated average daily intake of chromium (VI) from the
treated rice was 40.9 µg/bird. The control chickens were fed non-spiked
rice, and the background daily exposure to total chromium from this rice
was around 3.5 µg/bird. No effects were seen over this time period on
body weight, organ weights or haematological parameters, and no gross or
histological changes attributable to the exposure were found in liver,
spleen, kidneys, heart, lungs and gonads. Similar results were found in
experiments with mice (Rao et al., 1983).
The available mammalian toxicity data are reviewed in Section 4 of the
EU RAR (2005).
The most relevant results from these data are a no observed adverse effect level (NOAEL) of 20 mg Cr (VI)/kg body weight/day for effects on the testes in mouse (oral gavage route) and a LOAEL of 20 mg Cr (VI)/kg body weight/day for developmental effects in mice (drinking water route). For the purpose of this assessment the 20 mg/kg bw value is used, recognising that in one of the studies effects were seen at this level.
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for birds:
- 20 mg/kg food
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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