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EC number: 233-020-5 | CAS number: 10022-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The justification for read across is attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 6.65 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- dissolved Ba(NO3)2
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 3.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- dissolved Ba
- Basis for effect:
- mortality (fish)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29.03.2010 - 02.04.2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2009-03-04
- Analytical monitoring:
- yes
- Details on sampling:
- Samples from test solutions were taken for analysis of actual test item concentrations in comparison to the nominal concentrations. The test solutions were vigorously stirred by use of a steel blade in order to homogenise the suspension. Samples were taken immediately after stirring.
A sample of the stock solution was taken, and samples of the test concentrations (incl. control) were taken at the start and end of the test period.
Immediately after sampling and before shipment, the samples were stored in polyethylene bottles in the refrigerator. - Vehicle:
- no
- Details on test solutions:
- Reconstituted water according to OECD guideline No. 203 was used to dilute the test item and to keep the fish before and during the period of the test. Local tapwater was treated by reverse osmosis and ion-exchanger to prepare deionised water. Therefore a contamination with heavy metals, pesticides and TOC is excluded.
The reconstituted water consists of deionised water and salts in the following final concentrations:
A) CaCl2 * 2 H2O: 294.0 mg/L
B) MgSO4 * 7 H2O: 123.0 mg/L
C) NaHCO3: 64.8 mg/L
D) KCl: 5.75 mg/L
Prior to use, the reconstituted water was diluted with deionised water (1:1; v/v), and supplemented with 1% of artificial seawater.
Reconstituted water was used for the control. The test item was weighed in a plastic weighing boat. The test concentrations were prepared by dissolving 1289.4 mg of the test item in 10.998 L of reconstituted water (100 mg/L nominal) and 1957.7 mg in 11.011 L of reconstituted water (152 mg/L nominal) directly in the respective test vessel. The test solutions were stirred for approx. one minute before use. The test solutions appeared as milky suspension. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Organisms coming from ECT Oekotoxikologie GmbH, Germany (own breed; since November 2009)
- Average body weight of fish: 0.10 - 0.17 (mean: 0.12 g/fish; assessed from the total weight of a sample consisting of 10 fish)
- Average standard length of fish: 2.18 - 2.96 cm (mean: 2.69 cm; assessed in a sample consisting of 10 fish) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 171-179 mg/L as CaCO3
- Test temperature:
- 21.3 - 22.4 degrees Celcius
- pH:
- 7.1 - 7.5
- Dissolved oxygen:
- 94 - 105 %
- Nominal and measured concentrations:
- nominal: 66 and 100 mg Ba/L - 100 and 152 mg BaCl2/L - 117 and 178 mg/L test item
measured dissolved at t=0: below detection limit, 1.44, 3.35 mg Ba/L
measured dissolved at t=4d: below detection limit, 1.42, 3.68 mg Ba/L
measured total Ba at t=0: below detection limit, 62, 100 mg Ba/L
measured total Ba at t=4d: below detection limit, 64, 95 mg Ba/L
total expressed as test item (t=0): below detection limit, 111, 178 mg/L test item
total expressed as test item (t=4): below detection limit, 113, 170 mg/L test item - Details on test conditions:
- - Amount of test solution per test vessel: 10 L
- Depth of test solution in the test vessels: approx. 12.5 cm
- Number of fish per test vessel: 7
- Average length of fish: 2.69 cm (n = 10)
- Average weight of fish: 0.12 g (n = 10)
- Fish loading: 0.08 g per L
- Renewal of test solution and control water during the test period: none
- Feeding: none
- Photoperiod: light/dark - 16 h/8 h
- Light intensity: 100 - 1000 lx; measured: 312 - 321 lx
- Temperature (min / max): 21.3 / 22.2°C (daily measurements); 22.2 / 22.4°C (online measurements in one test vessel)
- Aeration: permanent - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 3.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 97.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- element (total fraction)
- Remarks:
- total Ba
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 174 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- There were no behavioural differences to be seen in fish in the treatments compared with the control fish. The fish were barely visible due to the milky appearance of the test suspensions.
The recovery of the test item in the 0.45 µm-filtered test solutions was between 2 and 4% of the nominal concentrations. The characteristics of the test item may have led to a precipitation in the test medium, probably as bariumsulfate.
The recovery of the test item in the non-filtered test solutions was between 95 and 100% of the nominal concentrations. - Reported statistics and error estimates:
- No statistical method was used to evaluate the fish mortalities because no mortality was observed during the test period in the control or the test item treatments.
- Sublethal observations / clinical signs:
Mortality in the control: none (required: ≤ 10%, or one out of seven fish)
Dissolved oxygen concentration in control and test vessels: ≥ 105% (required: ≥ 60% of air saturation value (ASV))
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 (96 h) based on measured concentrations in 0.45 µm-filtered test solutions was higher than 3.5 mg Ba/L.
The LC50 (96 h) based on measured concentrations in 0.45 µm-filtered test solutions was higher than 5.4 mg BaCl2/L.
The LC50 (96 h) based on measured concentrations in non-filtered test solutions was higher than 97.5 mg Ba/L
The LC50 (96 h) based on measured concentrations in non-filtered test solutions was higher than 149 mg BaCl2/L.
The LC50 (96 h) based on nominal concentrations was higher than 152 mg BaCl2/L.
These data can be used for hazard assessment purposes.
Referenceopen allclose all
Description of key information
No key study is available on the acute toxicity of barium dinitrate to fish. A read across approach was followed to cover this endpoint. The key study is a study from Egeler and Kiefer (2010) for barium chloride, performed using Danio rerio as test organism. The LC50 (96 h) based on mean measured dissolved Ba concentrations was > 3.5 mg Ba/L (equivalent to > 5.4 BaCl2/L). This result was recalculated to barium dinitrate based on the barium content of both substances (i.e. 6.65 mg barium trinitrate/L).
Key value for chemical safety assessment
Additional information
A single relevant and reliable study was available for the read across substance BaCl2 (Egeler and Kiefer, 2010). In this study, no mortality in Danio rerio was observed up to and including the highest test concentration (i.e., 152 mg BaCl/L, nominally). When based on mean measured concentrations (geometric mean), the 96-h LC50 for Danio rerio was > 3.5 mg dissolved Ba/L and > 97.5 mg Ba total/L. These values are equivalent to > 5.4 and > 149 mg BaCl2/L, respectively.
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