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EC number: 202-966-0 | CAS number: 101-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets general accepted scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- To develop a robust analytical method for the detection of very small amounts of MDI focusing on optimal sensitivity and selectivity
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4,4'-methylenediphenyl diisocyanate
- EC Number:
- 202-966-0
- EC Name:
- 4,4'-methylenediphenyl diisocyanate
- Cas Number:
- 101-68-8
- Molecular formula:
- C15H10N2O2
- IUPAC Name:
- 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
- Reference substance name:
- benzene, 1,1'- methylenebis[4-isocyanato-]
- IUPAC Name:
- benzene, 1,1'- methylenebis[4-isocyanato-]
Constituent 1
Constituent 2
Method
- Exposure assessment:
- measured
- Details on exposure:
- To demonstrate the applicability of the method for quantifying values of the specific MDI adduct, two different sample groups were selected. The first group was formed from 25 workers from an MDI plant dealing with MDI during their work shift. The second group was formed from 40 people not knowingly exposed to MDI. Urine and blood samples (EDTA blood collected by venipuncture) were collected during the periodically occurring occupational health examinations at the end of the work shift. The biomonitoring program included the determination of MDA in urine after acid hydrolysis and MDA as a hemoglobine adduct after mild alkaline hydrolysis as well as the detection of the specific hemoglobin aduct ABP-Val-hyd.
Results and discussion
Any other information on results incl. tables
Several haemoglobin samples were analysed to obtain an overview of possible levels of exposure to MDI. In the workers (n = 25) exposed to MDI the specific MDI marker ABP-Val-Hyd was detected in 22 of these samples at 0.15-16.2 pmol/g, whereas MDA derived from hydrolysis was only found in 8 samples in a range between 0.35 and 1.12 pmol/g. In 40 globin samples from people not knowingly exposed to MDI, the amounts of ABP-Val-Hyd were below the LOQ demonstrating the selectivity of the method. It was also demonstrated that the method presented is robust, specific and sensitive for the analytical detection of the specific MDI metabolite ABP-Val-Hyd at a very low level.
Applicant's summary and conclusion
- Conclusions:
- The results for MDA in urine after acid hydrolysis cover an exposure period of the previous 2 or 3 days. They can only be used as a short-time marker of MDA/MDI exposure after the work shift. As described before, these data do not allow one to distinguish between MDA or MDI exposure. In contrast the ABP-Val-Hyd is a specific and long-time marker for MDI exposure.
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