2-butoxyethanol

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1993

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: A reasonably well reported study that conforms to basic scientific principles and contributes to the understanding of the sensitising potential of this substance.

Data source

Reference

Reference Type:

publication

Title:

Can chemicals precipitate dermatitis herpetiformis ?

Author:

Snider RL and Maize JC

Year:

1993

Bibliographic source:

J. Am. Acad. Of Dermatology, 28 (1), 111-112.

Materials and methods

Type of sensitisation studied:

skin

Study type:

case report

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

Not applicable - case report

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-butoxyethanol

EC Number:

203-905-0

EC Name:

2-butoxyethanol

Cas Number:

111-76-2

Molecular formula:

C6H14O2

IUPAC Name:

2-butoxyethanol

Details on test material:

An industrial cleaner. Analysis of the mixture showed the presence of 2-butoxyethanol, trisodium phosphate, nonylphenol polyethylene glycol ether, anthraquinone, lemon fragrance and an antifoam agent.

Method

Type of population:

occupational

Subjects:

CASE 1
- Number of subjects exposed: 1
- Sex: female
- Age: 49
- Race: white

CASE 2
- Number of subjects exposed: 1
- Sex: male
- Age: 43
- Race: white

Clinical history:

CASE 1: History of erythematous, papular eruption on hands, face and trunk. Treated with corticosteroids successfully. As this was resolving, intense pruritic vesicular eruptions developed on elbows, knees, abdomen. Biopsy findings found to be consistent with DH.
CASE 2: several hours after exposure, intense burning and tingling in hands, puritic eruption of grouped vesicles on hands and forearms. Biopsy findings found to be consistent with DH.

Controls:

no data

Route of administration:

dermal

Details on study design:

Patch testing on unaffected skin of the back was carried out with the individual chemicals of the mixture and at the same concentration than in the mixture (except for 2-butoxyethanol which was diluted to avoid irritation)

Results and discussion

Results of examinations:

There was no reported reaction to 2 -butoxyethanol.

Applicant's summary and conclusion

Conclusions:

2-butoxyethanol was not the cause of dermatitis herpetiformis in two occupational case studies.

Executive summary:

Two cases of dermatitis herpetiformis (DH) temporally related to the use of a cleaning solution containing 2 -butoxyethanol (2BE) have been reported. Analysis of the mixture showed the presence of 2 -butoxyethanol amongst a number of other materials. Patch testing was carried out with the individual chemicals at the same concentration than in the mixture, except for 2BE which was diluted to avoid irritation). There was no reported reaction to 2 -butoxyethanol in the patch tests whereas some of the other chemicals caused an adverse response.