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EC number: 231-957-4 | CAS number: 7782-49-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-01-16 to 1996-02-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- February 24, 1987
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 31 July 1992
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Selenium
- EC Number:
- 231-957-4
- EC Name:
- Selenium
- Cas Number:
- 7782-49-2
- Molecular formula:
- Se
- IUPAC Name:
- selenium
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Selenium powder 200
- Substance type: inorganic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wistar outbred rat; Crl :(WI) WU BR; Charles River Wiga, Sulzfeld, Germany
- Age at study initiation: 5 -6- weeks old upon arrival
- Weight at study initiation: males 278 to 299 g, females 158 to 183 g
- Fasting period before study: fasted overnight
- Housing: five animals per cage (stainless steel cages, fitted with wirescreen floor and front)
- Diet (e.g. ad libitum): standard laboratory rodent diet ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: 41 or 44 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%):between 42.5-75%
- Air changes (per hr): ca 10 air changes/hour
- Photoperiod (hrs dark / hrs light): 12 hours Iight/12 hours dark cycle
IN-LIFE DATES: From 1995-12-06 To: 1996-02-02
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 500 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10mL/kg bw - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- A screening was carried out with two females, since no mortality was observed, the study was continued with three males and five females
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were made within 1 hour and within 4 hours after dosing, and subsequently at least
once daily throughout an observation period of 14 days.
Body weight of each animal was recorded immediately before dosing on day 0, and on day 3, 7 and 14 of the study.
- Necropsy of survivors performed: yes; the abdomen and the thorax of each animal was opened and examined for gross pathological changes.
- Other examinations performed: clinical signs - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No animal died
- Mortality:
- No mortality occurred
- Clinical signs:
- other: Sluggishness was observed in 3 males and in 1 female. Piloerection was observed in all males and females. Diarrhoea was observed in 2 males and in 3 female at 24 and 48 hours after dosing. Apart from some signs of alopecia in all females prior to and duri
- Gross pathology:
- Examination of the animals at autopsy did not reveal any treatment-related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP; EU GHS (Regulation (EC) No 1272/2008)
- Conclusions:
- The LD50 for Selenium (powder) was determined to be > 5000 mg/kg bw .
- Executive summary:
In an acute oral toxicity study according to OECD Guideline 401 (Acute Oral Toxicity), wistar rats (5 animals/sex) were given a single oral dose of 5000, mg/kg bw Selenium (powder) in maize oil and observed for 14 days.
No mortality occurred during the 14-day observation period, apart from sluggishness, piloerection and diarrhoea, no other clinical symptoms were observed.
A slight dip in body weight was observed on day 3 of the study only. Macroscopic examination of the animals at the end of the observation period did not reveal any treatment-related gross alterations.
In conclusion since no mortality occurred during the 14-day observation period, the oral LD50, of Selenium (powder) is considered to exceed 5000 mg/kg body weight, in both male and female rats.
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