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EC number: 202-615-1 | CAS number: 97-88-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- DATA QUALITY: Study was conducted in accordance with a recognized scientific procedure for determining the acute dermal toxicity of a test substance, following GLP regulations. The study meets national and international scientific standards and provides sufficient information to support the conclusions regarding the acute dermal toxicityof n-Butyl Methacrylate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Butyl methacrylate
- EC Number:
- 202-615-1
- EC Name:
- Butyl methacrylate
- Cas Number:
- 97-88-1
- Molecular formula:
- C8H14O2
- IUPAC Name:
- butyl methacrylate
- Details on test material:
- - Supplier: Du Pont
- Name of test material (as cited in study report): n-Butyl athacrylate
- Physical state: liquid
- Analytical purity: 99.49 %
- Purity test date: no data
- Lot/batch No.: 19845
- Expiration date of the lot/batch: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hare Marland, Hewitt, NJ, USA
- Age at study initiation: young adult
- Weight at study initiation: 2550 +/- 103 g for males and 2536 +/- 59 g for females
- Housing: singly in stainless steel , wire-mesh cages
- Diet (e.g. ad libitum): Purina certified high fiber rabbit chow #5325
- Water (e.g. ad libitum): tap water
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
- Humidity (%): 50 +/- 10
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 190 cm²
- % coverage: 10
- Type of wrap if used: oclusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with soap and water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
- Constant volume or concentration used: no - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- The day before dosing each rabbit's hair was shaved between the scapular and lumbar region of the back. Animals were fitted with a plastic Elizabethan collar toprevent ingestion. The test material was then spread evenly over a gauze pad (about 190 sq. cm or 10% of the bodysurface area) and then this was applied to the exposed skin site and held in contact by impervious bandages for 24 hours. After 24 hours the bandages were removed and the skin sites washed with soap and water. Dermal effects were scoredaccording to Draize. Animals were observed for mortality,body weight change (days 1, 7 adnd 14) and general behavior throughout the study. All animals were subjected to a gross necropsy after a 14 day observation period.
- Statistics:
- Not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- There were no deaths.
- Clinical signs:
- other: Slight to moderate erythema but no edema was observed in all animals 1 day after application of the test substance. Red spots vere observed in the treated skin of 1 animal. By day 4 after application, no or moderate to severe erythema but no edema vas obs
- Gross pathology:
- Treatment-related discoloration vas noted in the treated area of 4 male and 2 female rabbits at necropsy. Other gross observations vere believed to be spontaneous and/or incidental lesions. No target organ vas identified.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Conclusions:
- In a valid guideline study the acute dermal LD0 in rabbits was >2000 mg/kg bw.
- Executive summary:
In an OECD 402 and GLP study, a single dose of n-butyl methacrylate was applied to the shaved, intact skin of 5 male and 5 femaleNew Zealand White rabbits at a dosage of 2000 mg/kg of body weight. The application site was occluded for 24 hours. The rabbits were observed for 14 days following application.
No rabbits died within 14 days after dosing. No to severe erythema and no to severe edema were observed in the treated rabbits during the study. Superficial necrosis was observed in 1 rabbit on day 4 after application of the test substance and in most other rabbits by day 12 after application. Two rabbits also exhibited necrosis during the study. No target organ was identified at necropsy.
Under the conditions of this test, the acute dermal LD0 for n-butyl methacrylate was greater than 2000 mg/kg of body weight.
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