Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-902-6 | CAS number: 75-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. It was not compliant with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Remarks:
- Although a GLP statement was not included with the report, it is known that Bushy Run Research Center (BRRC) operated as a GLP-facility at the time the testing was conducted.
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Trichloro(methyl)silane
- EC Number:
- 200-902-6
- EC Name:
- Trichloro(methyl)silane
- Cas Number:
- 75-79-6
- Molecular formula:
- CH3Cl3Si
- IUPAC Name:
- trichloro(methyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300g
- Fasting period before study: overnight
- Diet: commercial diet, ad libitum
- Water: municipal water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Silicone L-45 oil
- Details on oral exposure:
- Hiltop-Wistar albino rats received the test material as a 25% dilution in Silicone L-45 oil by stomach intubation with a ball-end stainless steel needle.
- Doses:
- The test material was administered undiluted t first at 0.25 ml/kg to males and 1 ml/kg to females. It was then administered as a dilution in Silicone L-45 Oil as follows; 8, 4, 2, 1, and 0.5 mL/kg in males; 8, 4, 2, and 1 mL/kg in females.
- No. of animals per sex per dose:
- 5 animals/sex/dose for a total of 45 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animal weights were recorded at 0 days (before dose), 7 days and 14 days (just prior to sacrifice).
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: - Statistics:
- LD50s were calculated by the moving average method (Thompson, 1947) and were based on a 14-day observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.62 mL/kg bw
- 95% CL:
- 0.903 - 2.92
- Remarks on result:
- other: sample dosed as a 25% dilution in Silicone L-45 oil
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2.83 mL/kg bw
- 95% CL:
- 2.09
- Remarks on result:
- other: sample dosed as a 25% dilution in Silicone L-45 oil
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- < 0.25 mL/kg bw
- Remarks on result:
- other: Sample dosed undiluted
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- < 1 mL/kg bw
- Remarks on result:
- other: Sample dosed undiluted
- Mortality:
- See Table 1 and 2.
- Clinical signs:
- other: MALES Dosage: 8 mL/kg: Dyspnea at 3 min; death at 7 to 20 min Dosage: 4 mL/kg: sluggishness, dyspnea at 30 min Dosage: 2 mL/kg: Death of 2 at 4 hr Dosage: 1 mL/kg: None noted before death Dosage: 0.5 mL/kg: None noted FEMALES Dosage: 8 mL/kg: Sluggishnes
- Gross pathology:
- MALES
Dosage: 8 mL/kg: Stomach distended, gas and liquid-filled, injected, walls brittle, glandular portions black; livers brown, firm; pancreas brown; intestines brown and firm near stomach, lower areas red; kidneys brown, firm; spleens enlarged
Dosage: 4 mL/kg: In victims, lungs red; stomach of 1 perforated; livers pale, firm; intestines injected; adrenals red. In survivors, nothing remarkable
Dosage: 2 mL/kg: In victims, clear fluid in thoracic cavity; stomachs enlarged, black, 1 perforated; intestines brown; fluid in abdominal cavity; spleens enlarged. In survivor, nothing remarkable
Dosage: 1 mL/kg: In victims, lungs pink or red. In survivors, nothing remarkable
Dosage: 0.5 mL/kg: Nothing remarkable
FEMALES
Dosage: 8 mL/kg: Stomachs liquid-filled, injected, glandular sections black, firm; livers tan, firm near stomach; intestines tan and firm near stomach, red and injected in lower areas; kidneys tan, firm
Dosage: 4 mL/kg: Similar to above; 1 stomach perforated; 2 with fluid in abdominal cavity
Dosage: 2 mL/kg: Lungs with dark red patches
Dosage: 1 mL/kg: Nothing remarkable
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occurred when dosed with undiluted sample.
Dose |
Mortality (# dead/total) |
Time range of deaths (day) |
||
Male |
Female |
Combined |
||
0.25 |
5/5 |
n/a |
5/5 |
0,1,2 |
1.0 |
n/a |
4/5 |
4/5 |
0 |
Table 2: Number of animals dead and time range within which mortality occurred when dosed with diluted sample
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
||
Male |
Female |
Combined |
||
0.5 |
0/5 |
n/a |
0/5 |
- |
1.0 |
2/5 |
0/5 |
2/10 |
1,2 |
2.0 |
4/5 |
0/5 |
4/10 |
0,1,2 |
4.0 |
3/5 |
5/5 |
8/10 |
1,2,5 |
8.0 |
5/5 |
5/5 |
10/10 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 values of <320 mg/kg for males and <1280 mg/kg for females were determined in a reliable study conducted according to an appropriate test protocol. Not conducted according to GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.