Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-871-9 | CAS number: 75-45-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In tests for metabolism and pharmacokinetics chlorodifluoromethane was evaluated in groups of 3 male humans exposed via inhalation to vapor concentrations of 92 or 518 ppm for 4 hours in an inhalation chamber. The compound was absorbed very quickly, reaching plateaus of 0.25 and 1.36 ug/ml after approximately 4 and 3 hours of exposure for the low- and high-dose levels, respectively. End-tidal breath concentrations of the test compound during exposure were similar to the exposure concentrations, indicating that only a small proportion of the available dose was absorbed. Elimination of the compound from blood was triphasic, with estimated half-lives of 0.005, 0.20, and 2.7 hours. The first phase probably corresponded to elimination from blood and rapidly perfused tissues, whereas the second and third phases of elimination probably corresponded to elimination from slowly perfused tissues and fat, respectively. The parent compound was detected in urine samples from all subjects; very little fluoride ion was detected in urine samples, indicating that the test compound was probably not metabolized to a significant extent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
