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EC number: 294-415-6 | CAS number: 91722-14-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April-July 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been conducted according to OECD guideline and under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Soybean oil, epoxidized, acrylate
- EC Number:
- 294-415-6
- EC Name:
- Soybean oil, epoxidized, acrylate
- Cas Number:
- 91722-14-4
- Molecular formula:
- C63H108O15
- IUPAC Name:
- Soybean oil, epoxidized, acrylate
- Details on test material:
- - Name of test material (as cited in study report): C-SAT 040012 (PHOTOMER 3005 F)
- Substance type: UVCB
- Physical state: yellowish, viscous liquid
- Analytical purity: 100%
- Lot/batch No.: S74.0750027
- Expiration date of the lot/batch: 15 September 2004
- Storage condition of test material: room temperature, protected from light
Constituent 1
Method
- Target gene:
- histidine gene in Salmonella typhimurium
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver S9 mix
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: ethanol
- Justification for choice of solvent/vehicle:
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: Without metabolic activation: sodium azide for TA 1535 and TA 100; 4-nitro-o-phenylene-diamine for TA 1537 and TA 98; methyl methane sulphonate for TA 102. With metabolic activation: 2-aminoanthrace with all strains.
- Details on test system and experimental conditions:
- The assays were performed in four independent experiments, all with and without liver microsomal activation. Due toxic effects caused by the solvent ethanol in exp. II in strain TA 100 without S9 mix and strain TA 102, with and without S9 mix, this experiment was repeated twice. Once with application volume of 100 µl (not reported) and a second with an application volume of 50 µl (reported as exp. II). Each concentration, including the controls, was tested in triplicate.
- Evaluation criteria:
- The Salmonella typhimurium reverse mutation assay is considered acceptable if it meets the following criteria:
- regular background growth in the negative and solvent control
- the spontaneous reversion rates in the negative and solvent control are in the range of the historical control data of the laboratory
- the positive control substances should producer a significant increase in mutant colony frequencies
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- A reduced background growth was observed from 2500 to 5000 µg/plate with and without metabolic activation in the first experiment and with metabolic activation in the second experiment. No toxic effects, evident as a reduction in the number of revertants, occurred in the test groups with and without metabolic activation.
No substantial increase in revertant colony numbers of any of the five tester strains was observed following treatment with the test substance at any concentration level, neither in the presence nor absence of metabolic activation. There was also no tendency of higher mutation rates with increasing concentrations inthe range below the generally accepted border of biological relevance. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Under the experimental conditions reported, the test substance did not induce gene mutations by base pair changes or frameshifts in the genome of the strains used. Therefore, the test substance is considered to be non-mutagenic in the Salmonella typhimurium reverse mutations assay. - Executive summary:
The study was performed to investigate the potential of the test substance to induce gene mutations according to the plate incorporation test (experiment I) and the pre-incubation test (experiment II) using the Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and TA 102.
The assays were performed in four independent experiments, all with and without liver microsomal activation. Due toxic effects caused by the solvent ethanol in exp. II in strain TA 100 without S9 mix and strain TA 102, with and without S9 mix, this experiment was repeated twice. Once with application volume of 100 µl (not reported) and a second with an application volume of 50 µl (reported as exp. II). Each concentration, including the controls, was tested in triplicate.
The test substance was tested at the following concentrations: 33, 100, 333, 100, 2500 and 5000 µg/plate.
The plates incubated with the test item show normal background growth up to 5000 µg/plate with an without S9 mix in all strains used in experiment I. Reduced background growth was observed in experiment II from 2500 to 5000 µg/plate in strains with and without metabolic activation, only.
Toxic effects, evident as a reduction in the number of revertants, occurred in experiment II in strains TA 1537 (1000-5000 µg/plate) and TA 98 (2500-5000 µg/plate) without metabolic activation only.
No substantial increase in revertant colony numbers of any of the tester strains was observed following treatment with the test substances at any dose level, neither in the presence nor absence of metabolic activation (S9 mix). There was also no tendency og higher mutation rates with increasing concentrations in the range below the generally acknowledged border of biological significance.
Appropriate reference mutagens were used as positive controls and showed a distinct increase of induced revertant colonies.
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