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Diss Factsheets
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EC number: 241-234-5 | CAS number: 17194-00-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Carcinogenicity
Administrative data
Description of key information
According to the NTP study performed 1994, the concentration of 2500 ppm represents a NOAEL for carcinogenicity (corresponding to Ba doses of 60 and 75 mg/kg bw/d to male and female rats, respectively, and 160 and 200 mg/kg bw/d to male and female mice, respectively). Based on this value the NOAEL for Ba(OH)2 is calculated at 75 mg/kg bw/day.
Key value for chemical safety assessment
Justification for classification or non-classification
There was no evidence of carcinogenic activity (showing no chemical related increase of malignant or benign neoplasms) of barium chloride in both sexes of rats and mice that received 500, 1250, and 2500 ppm. Thus, the concentration of 2500 ppm represents a NOAEL (corresponding to barium doses of 60 and 75 mg/kg bw/d to male and female rats, respectively, and 160 and 200 mg/kg bw/d to male and female mice, respectively). No classification of the substance as CMR substance is required.
Additional information
Read across BaCl2*2H2O to Ba(OH)2:
The toxicity of barium hydroxide and barium chloride may reasonably be considered to be determined by availability of Ba2+cations. As a first surrogate for bioavailability, the water solubility of a test substance may be used. Barium chloride is highly water soluble with ca. 263 g/L at pH ca. 6.5 (510.4 g/L at pH 1.5). Also the water solubility of barium hydroxide is high (37.4 mg/L at pH > 13). Hence, any read across from barium chloride to barium hydroxide is considered to be justified and will likely lead to rather conservative no-effect levels.It is noted; although Ba(OH)2is a strong base (pH 13 for a 10% solution) it will be neutralised within the gastrointestinal tract (pH approx. 1.5 - 2).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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