Registration Dossier
Registration Dossier
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EC number: 701-374-4 | CAS number: -
Neurotoxicity
Administrative data
Description of key information
A subchronic neurotoxicity study of phenyl diisodecyl phosphite (PDDP) in hens showed some signs of neurotoxicity (distal peripheral neuropathy) in 2 of 10 hens at 4000 mg/kg bw/day. There were no neurotoxic effects observed at 1000 mg/kg bw/day.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
Adminstration of PDDP at doses of 100, 1000 and 4000 mg/kg/day for four weeks resulted in slight body weight losses at the hightest dose and possible test material-realted mortality at the middle and high dose. Although no neurotoxic effects were evident from antemortem evaluations, microscopic examination revealed a distal, peripheral neuropathy in two of the ten high-dose animals. No microscopic alterations were seen in low or mid dose animals. No altered NTE values attributed to PDDP administration were evident at any dose level.
Justification for classification or non-classification
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