Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 629-695-4 | CAS number: 164383-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
These results from Coconitrile can be regarded as valid for Tallownitrile as the tested substance is actually the same:They share the same chemical structure, and only differ in the average length of the alkyl chain. Aspects of sensitization are related to possible dermal penetration, and subsequent reactivity and protein binding (needed for haptenisation) which are properties that are relative independent to actual chain length. If anything, it is assumed that shorter chain lengths are possibly somewhat more bio-available, and thus the testing of Coconitrile might represent a worse case situation compared to Tallow.
Migrated from Short description of key information:
A GPMT study with Coconitrile showed no concern for sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
GPMT study on coconitrile performed under GLP and according to OECD guideline 406 resulted to a weak reaction in only 10% of the animals. Accordingly, no classification is required for dermal sensitisation. As chemical respiratory sensitisers also elicit positive results in predictive tests for contact sensitisation, the negative outcome for dermal sensitisation is also predictive for non respiratory sensitisation of the substance.
Migrated from Short description of key information:
A GPMT study with Coconitrile showed no concern for sensitisation.
Justification for classification or non-classification
A standard study to evaluate the sensitsing potential of coconitrile indicated that no classification is required for skin sensitisation. As such tests are also positive when tested with respiratory sensitisers, the non-sensitisng results of this tests also indicate that the substance is also not a respiratory sensitiser.
These results from Coconitrile can be regarded as valid for Tallownitrile as the tested substance is actually the same:They share the same chemical structure, and only differ in the average length of the alkyl chain. Aspects of sensitization are related to possible dermal penetration, and subsequent reactivity and protein binding (needed for haptenisation) which are properties that are relative independent to actual chain length. If anything, it is assumed that shorter chain lengths are possibly somewhat more bio-available, and thus the testing of Coconitrile might represent a worse case situation compared to Tallow.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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