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Diss Factsheets
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EC number: 203-825-6 | CAS number: 111-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Four OECD 301B studies are available for the substance. Of the four only one failed to reach 60% mineralisation by the end of the test. In a GLP study by Bellemain (2011) a total of 44.5 and 37.5% mineralisation was achieved on the 29thday falling short of the required 60% mineralisation and failing the 10 day window. Nevertheless, a review of the biodegradation plot reveals a lag time between 10 and 14 days prior to onset of biodegradation followed by a shallow degradation curve typical of highly insoluble substances which are poorly bioavailable and therefore only slowly degraded. There is no plateau at 29 days with a steady increase in mineralisation from days 18 to 29 from 20 to 40%. The toxicity control mirrors the activity observed in the test solutions.
In the three other studies:
1. 64.7% biodegradation was achieved in a 28 d GLP study by Schaefer & Matthews (2011) although the 10 day window was not met. Once again, Squalane was subject to a long lag phase of 10 days before the onset of mineralisation and this was once again followed by a linear mineralisation rate without a plateau as in the previous study, suggesting that the hydrophobicity of the substance is the rate limiting factor
2. 66.3% biodegradation was attained in a non-GLP OECD 301B study BfB (2011). Again, there was a long lag time of 11 days prior to onset of biodegradation and a near linear mineralisation over the study such that the 10 d window was not achieved
3. 77% biodegradation was achieved at the end of an ISO 17025 certified OECD 301B test, which should be considered the Key study, this time reaching the 10 day window. Once again a significant lag phase of 10 days was observed but the rate of mineralisation was more rapid than that found in the preceding studies. It should be noted that the ISO 17025 certification is not GLP but shares many aspects of this accreditation and for the purposes of this study should be considered comparable to GLP.Accreditation toISO/IEC 17025 demonstrates technical competence, therefore laboratories that are accredited to this standard are demonstrating that they follow 'good laboratory practice' and that the data produced is technically valid.
Based on the above information, the substance can be considered as readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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