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EC number: 203-457-6 | CAS number: 107-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: - non-standard, non GLP - limited information on methods, low number of animals
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A total of 6 rabbits (2 per dose group) were treated for 24h with 3-chloropropene dissolved in dipropyleneglycol monomethylester under occlusive conditions.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- - Name of test material (as cited in study report): allul chloride
- no further information given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: dipropyleneglycol monomethylester
- Details on dermal exposure:
- TEST SITE
- Area of exposure: stomach
- % coverage: no data
- Type of wrap if used: occlusive, rubber cuff
REMOVAL OF TEST SUBSTANCE
- no data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1, 0.2 and 0.398 g/Kg = 100, 200 and 398 mg/kg bw
- Concentration (if solution): 20 % (v/v)
- Constant volume or concentration used: no - Duration of exposure:
- 24 h
- Doses:
- 100, 200 and 398 g/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: pretreatment, on treatment day and weekly thereafter
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: - Statistics:
- no statistics conducted
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 398 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: rough estimate, as at this dose 1 of 2 animals died while all animals at lower doses survived
- Mortality:
- 100 mg/kg bw: 0/2
200 mg/Kg bw: 0/2
398 mg/Kg bw: 1/2 - Clinical signs:
- other: - survivors: scab formation is reported 8 and 15 d post treatment, no further information available - dead animal (high dose, observed 6 times on the day of exposure due to intensive reaction, timepoints not precisely reported): first observation: slight
- Gross pathology:
- not conducted
- Other findings:
- no data
Any other information on results incl. tables
Table 1: animal assignment and body weight development
|
Low dose |
Mid dose |
High dose |
|||
Dose (mg/kg bw) |
100 |
100 |
200 |
200 |
398 |
398 |
Cage No. |
1817 |
1818 |
1819 |
1820 |
1811 |
1812 |
Animal No. and sex |
427 male |
507 female |
481 female |
276 male |
363 male |
364 male |
Weight (kg) at d 0 |
2.27 |
2.50 |
2.43 |
2.68 |
2.95 |
2.98 |
Weight (kg) at d 1 |
2.22 |
2.41 |
2.49 |
2.74 |
2.85 |
2.99 |
Weight (kg) at d 8 |
2.50 |
2.72 |
2.57 |
2.70 |
Death at d 3 |
2.96 |
Weight (kg) at d 15 |
2.60 |
2.96 |
2.83 |
2.81 |
|
3.13 |
d 0 is the date of the start of the treatment
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A total of 6 rabbits (2 per dose group) were treated for 24h with 3-chloropropene dissolved in dipropyleneglycol monomethylester under occlusive conditions on the clipped skin with doses of 100, 200 and 398 mg/Kg in a non-guideline study.
1 of 2 animals died in the high dose group 2 days after the end of treatment probably due to severe skin burns and cyanosis. Based on this finding the high dose of 398 mg/Kg can be regarded as a rough estimate of a dermal LD 50 in the rabbit. - Executive summary:
In the present study (Dow K-1720-4A 1958) a total of 6 rabbits (2 per dose group) were treated for 24h with 3-chloropropene dissolved in dipropyleneglycol monomethylester under occlusive conditions on the clipped skin with doses of 100, 200 and 398 mg/Kg in a non-guideline study.
Animals were treated with the test item and subsequently observed for clinical signs. 1 of 2 animals of the high dose group showed signs of skin burns after teatment that were checked 6 times on the first day after exposure. This animal died 2 days after the end of treatment probably due to severe skin burns and cyanosis. For the other animals of the high and the mid dose scab formation after 8 and 15 days are reported.
Based on this finding the high dose of 398 mg/Kg can be regarded as a rough estimate of a dermal LD 50 in the rabbit.
The information available is limited therefore a reliability score of Klimisch 4 was assinged.
The determined LD50 of 398 mg/Kg bw triggers for 3 -chloropropene a classification as Category III (Danger, toxic in contact with skin) according to CLP as implementation of UN GHS in the EU (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL).
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