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Diss Factsheets
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EC number: 222-733-7 | CAS number: 3590-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study no performed in a GLP-certified laboratory; No standard or recognized guidelines followed; Solutions of organotins were not analyzed to verify concentrations; No information on statistical power, ranges of concentrations used, or control organisms were included in the report.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Relations between structure and insecticidal activity of some organotin compounds.
- Author:
- Blum, M.S. and J.J. Pratt, Jr.
- Year:
- 1 960
- Bibliographic source:
- Journal of Economic Entomology. 53:445-448.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other: unknown
- GLP compliance:
- no
- Remarks:
- Pre-dates GLP
- Application method:
- contact
Test material
- Reference substance name:
- Tetra-n-octyltin
- IUPAC Name:
- Tetra-n-octyltin
- Details on test material:
- - Name of test material (as cited in study report): Tetra-n-octyltin
- Molecular formula (if other than submission substance): (n-C8H17)4Sn
- Substance type: Mono-constituent substance
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No information.
Sampling and analysis
- Analytical monitoring:
- not specified
- Details on sampling:
- No data
Test substrate
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- - Method of test material application: Single topical dose
- Volume of test solution applied: 1 µL
- Controls: Vehicle control
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Acetone
- Concentration of vehicle in test medium (stock solution and final test solution): Not given
- Evaporation of vehicle before use: No
Test organisms
- Test organisms (species):
- Musca domestica
- Animal group:
- Diptera (house fly)
- Details on test organisms:
- TEST ORGANISM
- Common name: House fly
- Source: CHemical Specialties Manufacturers Association (susceptible strain)
- Age at test initiation (mean and range, SD): 3 to 4 days old
- Weight at test initiation (mean and range, SD): Not given
- Date of collection: Not given
- Cultural background (if honeybees): N/A
- Disease free: N/A
- Kept according to standard practices: N/A
ACCLIMATION
- Acclimation period: 3 to 4 days following emergence from pupation
- Acclimation conditions (same as test or not): Same as test
- Feeding: Purina dog pellets, moistened for larvae; adults were fed a water suspension of powdered skimmed milk.
- Health during acclimation (any mortality observed): Not given
Study design
- Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- No additional information.
Test conditions
- Test temperature:
- 32 +/- 1°C
- pH (if soil or dung study):
- N/A
- Humidity:
- 50% +/- 5%
- Photoperiod and lighting:
- Not given
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): Exposed flies contained in Mason jars
- Amount of soil or substrate: N/A
- No. of organisms per treatment: 40
- No. of replicates per treatment group: Four
- No. of replicates per control: N/A
- No. of replicates per vehicle control: Unclear
OTHER TEST CONDITIONS
- Photoperiod: Not given
- Light intensity: Not given
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality
VEHICLE CONTROL PERFORMED: Yes
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Unclear, tetraoctyltin test concentrations not given
- Justification for using less concentrations than requested by guideline: N/A
- Range finding study
- Test concentrations: Not given
- Results used to determine the conditions for the definitive study: Not given - Nominal and measured concentrations:
- Only LC50 value reported
- Reference substance (positive control):
- no
- Remarks:
- 42 other tin-containing compounds tested for toxicity
Results and discussion
Effect concentrations
- Dose descriptor:
- LC50
- Effect conc.:
- 196 other: x 10E-10 moles/fly
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Only house fly mortality was quantified
- Results with reference substance (positive control):
- Although no formal reference substance was utilized, the toxicity of nine tetraalkyl and tetraaryl stannanes were evaluated with the house fly model. Of these, tetra-n-octyltin was the most toxic compounds.
- Reported statistics and error estimates:
- Not reported
Any other information on results incl. tables
No relevant tables or figures included.
The tetra-substituted organotins do not exhibit much insecticidal activity and approximate the toxicities of the disubstituted organotins. The most toxic member of this series was tetra-n-octyltin. Toxicity increased regularly with chain length up to eight carbon atoms.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 (24h) for tetraocytltin is 196 x 10E-10 moles/fly.
- Executive summary:
The LC50 (24h) for tetraocytltin is 196 x 10E-10 moles/fly.
Tetraalkyl and Tetraryl Tin Derivatives:
The tetra-substituted oragnotins do not exhibit mush insecticidal activity and approximate the toxicities of the distributed organotins. The most toxic member of this series was tetra-n-octyltin. Toxicity increased regularly with chain length up to eight carbon atoms, except in the case of tetraisopropyltin. Replacement of two methyl groups with vinyl species does not affect toxicity, while replacement of the ethyl species of tetraethyltin with vinyl groups destroys toxicity. Whereas phenyl compares favorably with various alkyls as a tin substitute in the di- and trisubstitued organotins, the derivative produced by the arylation of tin is far less toxic, than the alkyls in the tetra-substituted species. Since cuticular penetration occurs most rapidly in the case of fat soluble materials and tetraphenyltin is relatively insoluble in most fat solvents, its lack of toxicity may possibly be attributable to poor penetration.
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