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EC number: 205-489-6 | CAS number: 141-57-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1994-11-22 to 1994-11-25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP, and was considered to be reliability 1 (reliable without restrictions). Read across to the registered substance is considered scientifically justified; the read across is considered to be reliability 2.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Test substance concentration determined in the stock solution used to prepare the test media.
Test substance concentration was determined in all treatments at the start and end of the test. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test media prepared by dilution of a 1000 mg/L stock solution prepared by mixing for 18 h followed by filtration. TOC concentration of stock solution determined. - Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Strain: 86.81.SAG
- Source (laboratory, culture collection): Institute for Water, Ground and Air Hygiene, Berlin (Germany)
- Age of inoculum (at test initiation): 3 days
- Method of cultivation: A pre-culture is produced from an original culture by super-inoculation three days before the test begins. From this culture the test cultures are inoculated at a density of about 20000 cells/ml. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- no data
- Test temperature:
- 24 +/-2ºC
- pH:
- Start of test: 8.3 - 8.7
End of test: 8.6 - 8.7 - Dissolved oxygen:
- no data
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0(Control), 101, 172, 304, 507 and 913 mg/L
Measured concentrations at start of test in treatments: 99, 161, 311, 550 and 975 mg/L
Measured concentrations at end of test in treatments: 84, 148, 260, 475 and 1000 mg/L
Concentrations used as the basis for assessing effects: Control, 101, 172, 304, 507 and 913 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open Erlenmeyer flasks
- Material: glass
- Aeration: none
- Initial cells density: 20000 cells/mL
- Control end cells density: 560000 cells/mL
- No. of vessels per concentration (replicates): 5
- No. of vessels per control (replicates): 8
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
- Culture medium different from test medium: no
- Intervals of water quality measurement: start and end of test
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: no
- Photoperiod: continuous
- Light intensity and quality: 8000 Lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable):
- Determination of cell concentrations: spectrophotometer (absorption at 685 nm)
- Other:
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.7 - Reference substance (positive control):
- no
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 913 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 913 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test): none reported
- Any stimulation of growth found in any treatment: no - Reported statistics and error estimates:
- The were no toxic effects observed in the highest test concentrations and therefore statistical analysis of the results was not carried out.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 72-h EC50 value of >913 mg/L and NOEC of ≥913 mg/L have been determined for the effects of the test substance on growth rate of Desmodesmus subspicatus (tested as Scenedesmus subspicatus) based on nominal concentrations of the substance. It is likely that the test organisms were exposed to the hydrolysis products of the substance.
Reference
Table 1. Test results
Nominal test substance concentration (mg/L) | Mean cell density at start of test (cells/mL) | Mean cell density after 24 hours (cells/mL) | Mean cell density after 48 hours (cells/mL) | Mean cell density after 72 hours (cells/mL) |
0 (Control) | 20000 | 20000 | 140000 | 560000 |
101 | 20000 | 20000 | 160000 | 710000 |
172 | 20000 | 30000 | 170000 | 710000 |
304 | 20000 | 30000 | 200000 | 760000 |
507 | 20000 | 30000 | 180000 | 730000 |
913 | 20000 | 50000 | 220000 | 800000 |
Description of key information
Toxicity to aquatic algae: 72 hour ErC50 >913 mg/l and NOEC ≥913 mg/l (mean measured DOC) (highest concentration tested) (EU Method C.3 (Algal Inhibition test)), read-across from an analogous/structurally related substance, trimethoxy(propyl)silane (CAS 1067-25-0). The observations in this study are attributed to the exposure of test organisms to the hydrolysis products in the test system.
Key value for chemical safety assessment
Additional information
There are no reliable toxicity to aquatic algae data available for trichloro(propyl)silane (CAS 141-57-1), therefore good quality data for an appropriate structural analogue, trimethoxy(propyl)silane (CAS 1067-25-0), have been read across. Both substances share the same silanol hydrolysis product, propylsilanetriol. The other hydrolysis products are hydrochloric acid and methanol, respectively. In the test with trimethoxy(propyl)silane (CAS 1067-25-0), the observations are attributed to the exposure of test organisms to propylsilanetriol in the test system. There is no basis to expect that methanol significantly influenced the results of the test. The toxicity of methanol is discussed further in the ecotoxicological information overview endpoint summary (additional information).
A 72-hour ErC50 value of >913 mg/l and a NOEC value of≥913 mg/l (mean measured DOC) (highest concentration tested) have been determined for the effects of trimethoxy(propyl)silane (CAS 1067-25-0) on growth rate of Desmodesmus subspicatus. In view of the test media preparation method and exposure regime it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance. The test concentrations are reported in terms of DOC and are therefore not further adjusted in terms of concentration of parent corrected to concentration of silanol.
Above a concentration of approximately 1000 mg/l, dimeric / oligomeric, cyclic or cross-linked condensation products could potentially form over time in the aqueous test media. No evidence of undissolved material (parent substance or precipitated products) is indicated in the study report for this test.
Refer to the discussion in the Section 6 endpoint summary (Section 7.0 of CSR) for further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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