Registration Dossier
Registration Dossier
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EC number: 204-558-8 | CAS number: 122-62-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List IV
- Author:
- Smyth H, Carpenter CP, Weil CS
- Year:
- 1 951
- Bibliographic source:
- AMA Arch . Ind . Hyg . Occ . Med . 9 :119-122.
Materials and methods
- Principles of method if other than guideline:
- The shaved skin of rabbits was treated with the neat test substance. There was no indication of occluding the area or the length of treatment.
- GLP compliance:
- no
- Test type:
- other: not specified
Test material
- Reference substance name:
- Bis(2-ethylhexyl) adipate
- EC Number:
- 203-090-1
- EC Name:
- Bis(2-ethylhexyl) adipate
- Cas Number:
- 103-23-1
- Molecular formula:
- C22H42O4
- IUPAC Name:
- bis(2-ethylhexyl) adipate
- Details on test material:
- CAS no: 103-23-1
Lot no: LDJ4348
Purity: 99.8%
Supplier: Wako Pure Chemical Industries (Tokyo, Japan)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- The shaved skin of rabbits was treated with the neat test substance. There was no indication of occluding the area or the length of treatment.
- Duration of exposure:
- The observation period was 14 days post-treatment.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 15 029 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The shaved skin of rabbits was treated with the neat test substance. There was no indication of occluding the area or the length of treatment. The observation period was 14 days post-treatment. No data were provided other than the estimated LD50. LD50: 15029 mg/kg
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