Registration Dossier
Registration Dossier
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EC number: 200-824-2 | CAS number: 74-95-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
- Quality of whole database:
- No reliable acute oral toxicity data is available. However, from the results of a 14-day range-finding study for a reproduction/developmental toxicity study LD50 is > 1000 mg/kg bw/day can be concluded.
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 4 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 000 mg/kg bw
Additional information
Several studies explored the acute toxicity of dibromomethane via the 3 main exposure routes (oral, dermal, and inhalation).
In a 4-hour inhalation study in rats receiving about 20 mg/L to 21-22 mg/L dibromomethane in air, no mortalities occurred and no lasting pathological changes were seen at 18 and 20 days post treatment. LC50> 22.3 mg/L was observed.
Oral LD50was > 1000 mg/kg/bw was derived from a 14 day day range-finding study for a reproduction/developmental toxicity study conducted according to OECD TG 421 and US EPA OPPTS 870.3550.
No reliable acute dermal toxicity information is available. The results from a secondary source suggest dibromomethane is of low toxicity via the dermal route (LD50 > 4000 mg/kg bw/day).
Justification for selection of acute toxicity – oral endpoint
Most reliable source
Justification for selection of acute toxicity – inhalation endpoint
Most reliable source
Justification for selection of acute toxicity – dermal endpoint
Only available information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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