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EC number: 203-646-3 | CAS number: 109-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- -reliability scoring based on 1987 guideline
- Deviations:
- yes
- Remarks:
- purity and physico-chemical properties of test substance, sex and strain of animals, temperature, humidity, light cycle, and individual clinical signs were not reported; less than 3 dose levels tested; and less than 5 animals/sex/dose group tested
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-chloropyridine
- EC Number:
- 203-646-3
- EC Name:
- 2-chloropyridine
- Cas Number:
- 109-09-1
- Molecular formula:
- C5H4ClN
- IUPAC Name:
- 2-chloropyridine
- Details on test material:
- - Name of test material (as cited in study report): Olin 757 (2-Chloropyridine; PD-646)
- Physical state: Liquid (clear light yellow)
- Analytical purity: Not reported. The author reported that the test compound was considered to be free of impurities.
- Lot/batch No.: Not reported
- Expiration date of the lot/batch: Not reported
- Stability under test conditions: Not reported
- Storage condition of test material: Not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: 2040 to 2828 g
- Fasting period before study: Not reported
- Housing: Rabbits were confined in specially constructed stock designed to hold the animal immobile (in a highly ventilated room). Twenty-four hours after application of the test compound, the animals were transferred to individual metal cages for the duration of the observation period.
- Diet (e.g. ad libitum): food was provided ad libitum
- Water (e.g. ad libitum): water was provided ad libitum
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: Not reported
- Type of wrap if used: Not reported
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Area of application was bathed with warm water.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not reported, but can be calculated for each rabbit based on initial body weight and on the density of the test substance (1.265 mg/mL)
- Concentration (if solution): Not applicable - Duration of exposure:
- 24 hours
- Doses:
- 200 or 2000 mg/kg body weight
- No. of animals per sex per dose:
- 3 animals/sex/dose
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: frequently during the first 4 hours after application, at 24 hours, and once daily thereafter for a total of 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: LD50 was not identified
- Effect level:
- other: no LD50 identified
- Remarks on result:
- other: 5 out of 6 rabbits died in the 200 mg/kg body weight dose group and all rabbits died in the 2000 mg/kg body weight dose group
- Mortality:
- 200 mg/kg body weight dose group:
2 animals died within 18 hours; 3 animals died within 48 hours; and one animal with intact skin survived at the end of the study period
2000 mg/kg body weight dose group:
All animals tested died within 18 hours. - Clinical signs:
- other: Death was preceded by cyanosis, bradypnea and dyspnea, lacrimation, hypothermia, and hypotonia of the skeletal musculature for both dose groups. The one animal that survived at the end of the study period (administered 200 mg/kg body weight) demonstrated
- Gross pathology:
- Rabbits at the 200 mg/kg body weight dosage level exhibited excessive mucous in the stomach, as well as lungs which failed to collapse, and which were congested and hemorrhagic. Fluid was found in the thoracic cavity and a strong odor of compound was present in the thoracic cavity. One animal displayed a hemorrhagic cecum. The surviving rabbits in this group exhibited no gross lesions.
At the 2000 mg/kg body weight dosage level all rabbits exhibited excessive mucous in the stomach, lungs which failed to collapse and which were congested and hemorrhagic. Foam was present in the trachea and major bronchi. A strong compound odor was present in the thoracic cavity of all rabbits at this dosage level. - Other findings:
- Dermal irritation:
All 3 rabbits which survived the 200 mg/kg body weight dose level for 48 hours exhibited mild erythema and edema at the 24-hour evaluation period. The one rabbit surviving this dose level for the entire 14-day observation period exhibited mild erythema for the entire period. The authors concluded that based on the dermal irritation observed in the one animal which survived the full 14-day observation period, 2-chloropyridine does not produce severe irritation to the skin when applied in the manner described.
Applicant's summary and conclusion
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