Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-328-4 | CAS number: 105-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Activated sludge (3 hr): EC50 = 488.6 mg/; EC20 = 149.1 mg/l; EC10 = 80.2 mg/l
Pseudomonas putida (5 hr): EC10 = 1003 mg/l
ETAD fermentation tube (1986/2009) (24 hrs): EC0 = 63 mg/l
ETAD fermentation tube (1977) (24 hrs): Toxicity Threshold (TT) = 40 mg/l
Key value for chemical safety assessment
- EC50 for microorganisms:
- 488.6 mg/L
- EC10 or NOEC for microorganisms:
- 80.2 mg/L
Additional information
Four studies are available where the toxicity to microorganisms has been investigated, two under aerobic and two under anaerobic conditions. In the anaerobic studies, the ETAD fermentation tube test was used as the test system. In both of them, the exposure period was 24 hours, which is far beyond the exposure period recommended in currently valid guidelines. Furthermore, as biodegradation in an STP is mainly an aerobic process, the toxicity to aerobic microorganisms is the more relevant endpoint. Therefore, the anaerobic studies serve as supporting information and were not taken into account for the identification of the key study.
In the first aerobic study, Pseudomonas putida was tested according to a modification of OECD 209 where activated sludge representing a community of microorganisms is used. The exposure period in this test was 5 hours, which is also beyond current standard. The resulting EC10 was 1003 mg/l. The second aerobic study was conducted according to OECD 209 with activated sludge from a domestic sewage treatment plant. There were no significant modifications of the test. The EC50 derived from this test was 488.6 mg/l, the EC20 was 149.1 mg/L, and the EC10 was 80.2 mg/L. As the EC50 derived from this study is lower than the one derived from the study with Pseudomonas putida, it was selected as the key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.