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EC number: 215-960-8 | CAS number: 1461-25-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 26 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Exposure of fish was performed either in a static, renewal, or flow-through system. Fish were exposed to 0, 20, 40, 60, 80 and 100 % of the stock solution for 96 hours.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- not specified
- Details on test solutions:
- - Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 98 µg/L liq-liq equil
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnow
- Age at study initiation (mean and range, SD): 31 days
- Length at study initiation (length definition, mean, range and SD): mean 19.7 mm, SD 0.823 mm
- Weight at study initiation (mean and range, SD): mean 0.109 g, SD 0.0157 g - Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 44.3 mg/L CaCO3 (± 0.65)
- Test temperature:
- 25.3 °C (± 0.21)
- pH:
- 7.7 ± 0.02
- Dissolved oxygen:
- 6.8 mg/L (± 0.29)
- Nominal and measured concentrations:
- Nomianl: 0, 20, 39, 59, 78 and 98 µg/L
- Details on test conditions:
- TEST SYSTEM
- Tank volume: 0.25 L
- No. of organisms per vessel: 10
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Lake Superior water
- Additions: 40.3 V/D
- Alkalinity: 44.1 mg/L CaCO3 (± 2.17)
OTHER TEST CONDITIONS
- Adjustment of pH: When the pH of the stock was outside the range of 7 to 8, the pH was adjusted to approximately that of the Lake Superior water (pH 7.7) with either NaOH or concentrated HCl.
Control had 0 µg/L of toxicant. Percent recovery was 92.3 (3.83). Loading was 0.1082 G/L/D. FIsh were exposed to 0, 20, 40, 60, 80 and 100 % of stock solution. - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 45.2 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Conf. Lim: 41.6-49.2 µg/L
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 45.2 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: based upon loss of equilibrium as manifested by the fish's inability to maintain an upright position when swimming.
- Remarks on result:
- other: Conf. Lim: 41.6-49.2 µg/L
- Details on results:
- - Behavioural abnormalities: Affected fish were hyperactive, had increased respiration and lost equilibrium prior to death.
- Mortality of control: 0 - Reported statistics and error estimates:
- Estimated LC50 and EC50 with 95 % confidence intervals were calculated using the corrected average of the analyzed tank concentrations and the Trimmed Spearman-Karber Method.
Confidence limits could not be calculated under the following conditions: lack of monotonically increasing deaths or effects with expsoure concentrations, no complete (100 %) effect concentration, no unaffected (0 %) concentration and no concentration with a partial (>0 and <100 %) effect. - Sublethal observations / clinical signs:
Table 1: Test Concentrations
Date
Control
A
B
C
D
E
Nominal
0
20.0
39.0
59.0
78.0
98.0
01/26/87
<2.0
19
30
41
65
130
01/27/87
<2.0
19
37
40
78
82
01/28/87
<2.0
19
38
44
59
99
01/29/87
<3.1
19
42
54
72
01/30/87
<2.3
25
31
35
73
Average
< 2.30
20
36
43
69
102
Cor. Ave.
< 2.49
21.2
38.6
46.4
75.2
111
Percent recovery: 92.3 % (± 3.83) N = 4
Table 2: Mortalities
Mortalities Concentration (µg/L) Hours Control 20 39 59 78 98 Initial 10 10 10 10 10 10 24 8 48 10 10 72 2 10 10 96 8 10 10
Table 3: Observed effects
Effect Concentration (µg/L) Hours Control 20 39 59 78 98 Initial 10 10 10 10 10 10 24 8 48 10 10 72 3 10 10 96 8 10 10 - Validity criteria fulfilled:
- yes
- Conclusions:
- Affected fish were hyperactive, had increased respiration and lost equilibrium prior to death. 96 hr LC50: 45.2 µg/L, 96 hr EC50: 45.2 µg/L.
- Executive summary:
Fathead minnows were exposed to tetrabutyltin at nominal concentrations of 0 (control), 20, 39, 59, 78, and 98 µg/L. Fish were exposed to 0, 20, 40, 60, 80, and 100 % of the stock solution for 96 hours. Affected fish were hyperactive, had increased respiration and lost equilibrium prior to death. 96 hr LC50 was 45.2 µg/L and 96 hr EC50 was 45.2 µg/L.
Reference
Description of key information
Tetrabutyltin was determined to have a 96 hour LC50 value of 45.2 µg/L, along with an 96 hour EC50 value also of 45.2 µg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 45.2 µg/L
Additional information
Four studies are available to address this endpoint.
Short-term toxicity to fish.001: 96 hr LC50: 45.2 ug/L, 96 hr EC50: 45.2 ug/L
Short-term toxicity to fish.002: LC50: 9 µg/L
Short-term toxicity to fish.003: 96 hr LC50: 185 µg/L
Short-term toxicity to fish.004: 48 hr LC50: 5.21 mg/L
Short-term toxicity to fish.001 was selected as the key study on the basis that it was conducted for 96 hours and the methodology was well documented. The LC50 value obtained in the study was 45.2 µg/L, which was significantly lower than the other 96 hour study.
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