Registration Dossier
Registration Dossier
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EC number: 202-446-3 | CAS number: 95-74-9
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral, other
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- Peoples, S.A.: Progress Report on Starling Control, Divis-|ion of Agricultural Sciences, University of California|(1965): cited in Apostolou, A. and Peoples, S.A.: Proc.|Soc. Exp. Biol. Med. 134, 577-579 (1970)
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 002
- Details on test material:
- IUCLID4 Test substance: other TS: it is not specified, if the free base or the hydrochloride was used
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 10 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500 mg/kg bw/d
Basis:
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
following dosing the animals became ataxic, cyanotic and
comatose, this lasting from 30 minutes to 1 hour; it ap-
peared that males were affected more severely and recov-
ered much slower than females; with each additional feed-
ing the effects were less pronounced: after 4-5 days there
were little or no signs of postprandial toxicity; at aut-
opsy, a light-coloured liver having a nutmeg appearance of
fat infiltration was noted; the spleens were markedly con-
gested and almost black; again it was noted that the de-
scribed pathology was more severe in the males than fem-
ales although present in all; in the males there was appar-
ent atrophy of the seminal vesicles with normal appearing
testes; all other tissues were grossly normal; no deaths
occurred
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
