Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: guideline study and GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Report date:

2008

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione

EC Number:

700-064-6

Cas Number:

2105830-60-0

Molecular formula:

Not applicable as this is a UVCB substance

IUPAC Name:

Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione

Test material form:

liquid

Details on test material:

- Molecular weight: 2800-3000
- CAS Name: Castor oil. polymer with tetrahydromethyl-1,3-isobenzofurandione
- Description: Very viscous amber liquid
- Batch: NB2890-61
- Test substance storage: At room temperature in the dark under nitrogen
- Stability under storage conditions: Stable
- Expiry date: 01 January 2009

Results and discussion

Water solubility

Key result

Water solubility:

< 1 mg/L

Temp.:

20 °C

pH:

6.9

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): other: < 1 mg/l
After the stirring period, undissolved test substance was observed in the nominal 1.16 and 10.0 mg/l test solutions.

The Substance concentrations measured in the 1.16 and 10.0 mg/l test solutions after the second centrifugation step were 0.68 and 0.62 mg/l respectively. pH was 6.8 and 7.0 respectively.
It was however decided to report water solubility as < 1 mg/l because a response was observed in the blank which was in the same concentration range as the test samples. Concentration in two samples taken from the blank and treated in the same way as the test samples were 0.50 and 0.96 mg/l.
Concentration in the three-times centrifuged test sample was 1.0 mg/l which is even higher than the 0.62 mg/l concentration measured in the two-times centrifuged test sample. The three-times centrifuged sample might have been contaminated during treatment.
Based on these results, it was concluded that the water solubility of the Substance at
20.0 ± 0.5°C is < 1 mg/l.
Further testing was not performed because this would not result in a more accurate value for the water solubility.

Executive summary:

After the stirring period, undissolved test substance was observed in the nominal 1.16 and 10.0 mg/l test solutions.

The Substance concentrations measured in the 1.16 and 10.0 mg/l test solutions after the second centrifugation step were 0.68 and 0.62 mg/l respectively. pH was 6.8 and 7.0 respectively.

It was however decided to report water solubility as < 1 mg/l because a response was observed in the blank which was in the same concentration range as the test samples. Concentration in two samples taken from the blank and treated in the same way as the test samples were 0.50 and 0.96 mg/l.

Concentration in the three-times centrifuged test sample was 1.0 mg/l which is even higher than the 0.62 mg/l concentration measured in the two-times centrifuged test sample. The three-times centrifuged sample might have been contaminated during treatment.

Based on these results, it was concluded that the water solubility of the Substance at

20.0 ± 0.5°C is < 1 mg/l.

Further testing was not performed because this would not result in a more accurate value for the water solubility.