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Diss Factsheets
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EC number: 209-798-7 | CAS number: 593-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
- Remarks:
- Unsuitable test system, as the inhalation hazard test is insufficient for non-volatile substances
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VI
- Author:
- Smyth, H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 23, 95-107
Materials and methods
- Principles of method if other than guideline:
- Internal test method in accordance with Smyth HF et al., Am Ind Hyg Ass J 23: 95-107 (1962).
The inhalation hazard test demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at the temperature chosen for vapour generation (usually 20°C). Several groups of usually 3 rats per sex were sequentially exposed to the vapours, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted disc in a glass cylinder for different time periods. No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of the amount of the test substance weight loss during exposure. Group-wise documentation of clinical signs was performed over the 14 day study period. - GLP compliance:
- no
- Test type:
- other: Inhalation hazrad test
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(hydroxylammonium) sulphate
- EC Number:
- 233-118-8
- EC Name:
- Bis(hydroxylammonium) sulphate
- Cas Number:
- 10039-54-0
- Molecular formula:
- H3NO.1/2H2O4S
- IUPAC Name:
- bis(hydroxyammonium) sulfate
- Details on test material:
- Sulphate salt [10039-54-0], purity 99.5 % (not further
specified)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Average weight at study initiation: experiment 1: males ca. 220 g, females ca. 160 g; experiment 2: males ca. 220 g, females ca. 160 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no vehicle
- Details on inhalation exposure:
- Saturation of the atmosphere was generated by conducting an air stream through a substance layer of 5 cm height at 20 °C.
The rats were exposed to the test atmosphere for 7 hours. Air flow was 200 L/h in the exposure chamber. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- saturated vapour exposure
The concentration was almost 0 mg/L at 20 °C (after 7 hours the difference in weight was ), no volatile parts of the test material were generated; the nominal concentration was calculated as quotient of the amount of the test substance weight loss during exposure. - No. of animals per sex per dose:
- 12 per dose
- Control animals:
- no
- Details on study design:
- The exposure time not causing lethality was tested twice.
- Duration of post exposure period until necropsy: 14 days
- Frequency of weighing: Test animals were weighed at test initiation only
- Frequency of observations: The animals were observed following exposure after 3 min, 10 min, 30 min, 1 hour, 3 hours, 7 hours and thereafter daily
- Necropsy of survivors performed: yes. The necropsy of the animals was done on day 14 following exposure
Results and discussion
- Mortality:
- All animals survived within a 14-days observation period
- Clinical signs:
- other: no clinical signs were observed
- Body weight:
- The body weight was determined prior to the beginning of the study only.
- Gross pathology:
- Autopsy revealed no relevant findings.
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Since the result is depending on the vapour pressure of the test substance (being negligible at 20 °C for the tested material), an assessment of the inhalation toxicity is not possible. Nevertheless, the result supports the assumption that the test material is of low inhalation toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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