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EC number: 258-189-2 | CAS number: 52793-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-11-07 to 1989-11-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to EG-Guideline B.4. 84/449/EWG, OECD 404 and under GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: NaCL solution
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- after 30-60 min, 24, 48 and 72 hours
- Number of animals:
- 3 animals
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 30-60 min till 3 days
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 30-60 min till 3 days
- Score:
- 0
- Other effects:
- No.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Due to the test results, the test item is not irritating to the rabbit skin.
- Executive summary:
The study was performed according to EG-Guideline B.4. 84/449/EWG, OECD 404 and under GLP.
Due to the test results, the test item will not be classified as irritating to the rabbit skin and does not require labelling according toRegulation 1272/2008/EEC (CLP) and according to Directive 67/548/EEC (DSD).
Reference
Female rabbits:
Erythema, overall mean: 0.0
Oedema, overall mean: 0.0
The means have been calculated using the day 1,2 & 3 values.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-11-28 to 1989-12-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study documented and performed according to GLP standards and in compliance with Directive 84/449/EC, Part B, Method B5 and OECD Guideline 405.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- not applicable
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- Examination of the eyes was made after 1, 24, 48 and 72 hours after instillation. Observation of the eyes was aided by the use of
a handheld torch. - Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1, 24 , 48, 72 hours and 7 day
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1, 24 , 48, 72 hours and 7 day
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 8
- Max. score:
- 8
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Other effects:
- No corneal damage or iridial inflammation was seen throughout the observation period.
Conjunctival inflammation was evident in all three animals after one hour till 48 hours.
Conjunctival reddening and a slight swelling was noticed. Clear colorless eye defluxion was observed.
All reactions had resolved 72 hours after instillation. - Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item is not irritating to the rabbit eye.
- Executive summary:
The experimental procedure complied with EEC Methods for determination of toxicity Directive 84/449/EEC, Method B5 and OECD Guideline for testing of chemicals, 405. The study was documented and performed according to GLP standards.
Three New Zealand White strain albino rabbits were chosen in this test.
The test substance was administered unchanged in the conjunctival sac of the left eye.
Examination of the eyes were made after 1, 24, 48 and 72 hours after instillation.No corneal damage or iridial inflammation was seen throughout the observation period. Conjunctival inflammation was evident in all three animals after one hour till 48 hours. All reactions had resolved 72 hours after instillation.
In conclusion, the test item is not irritating to the rabbit eye and therefore has not been classified as irritating and does not require labelling according to Regulation 1272/2008/EEC (CLP) and according to Directive 67/548/EEC (DSD).
Reference
Animal No. |
1 |
2 |
3 |
3 hours/days |
1 24 48 72 7 |
1 24 48 72 7 |
1 24 48 72 7 |
Cornea |
|
|
|
E = Degree |
0 |
0 |
0 |
F = Area |
0 |
0 |
0 |
(F x E) x 5 |
0 |
0 |
0 |
D = Iris |
0 |
0 |
0 |
D x 5 |
0 |
0 |
0 |
Conjunctiva |
|
|
|
A = Redness |
2 1 1 0 |
2 2 1 0 |
2 2 1 0 |
B = Chemosis |
1 0 0 0 |
1 1 0 0 |
1 1 0 0 |
C = Discharge |
1 0 0 0 |
1 0 0 0 |
1 0 0 0 |
(A + B+ C) x 2 |
8 2 2 0 |
8 6 2 0 |
8 6 2 0 |
Total |
8 2 2 0 |
8 6 2 0 |
8 6 2 0 |
Group mean score at 1h: 8 Maximum mean score: 8
Group mean score at 24h: 5
Group mean score at 48h: 2
Group mean score at 72h: 0
Group mean score at 7d:----
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Study was conducted according to EG-Guideline B.4. 84/449/EWG, OECD 404 and under GLP.
Justification for selection of eye irritation endpoint:
Study documented and performed according to GLP standards and in compliance with Directive 84/449/EC, Part B, Method B5 and
OECD Guideline 405.
Justification for classification or non-classification
Based on the irritation/corrosion data available, the substance is not classified as irritating and does not require labelling according to Regulation 1272/2008/EEC (CLP) and according to Directive 67/548/EEC (DSD).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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