Registration Dossier
Registration Dossier
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EC number: 213-701-3 | CAS number: 1003-14-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Justification for read-across to 1,2 -Butenoxide:
No toxicokinetic data are available for n-Pentenoxide-1,2. However, a read-across to 1,2-Butenoxide, another member of the epoxide family can be made. The only structural difference between n-Pentenoxid-1,2 and 1,2-Butenoxide is the presence of an additional CH2-group in n-Pentenoxide-1,2. The chemical characteristics between these two substances are quite similar, with 1,2 -Butenoxide being more soluble in water (86.6 g/L vs 23 g/L water solubility), less lipophilic (log Pow=0.68 vs 1.29) and exhibiting a higher vapor pressure (227 hPa vs 70 hPa) as compared with n-Pentenoxide-1,2. It has been shown that the toxicities of epoxides decrease from ethylenoxide to propylenoxide to 1,2 -Butanoxide, suggesting that the toxicity of this reactive group of epoxide chemicals decreases with increasing length of the carbon backbone (Fox et al, 1983; NTP report No 267, 1985). In line with this assumption, the oral LD50 of 1,2-Butenoxide is smaller (900 mg/kg) as compared with n-Pentenoxide-1,2 (1460 mg/kg), further supporting the validity of a read-across from n-Pentenoxide-1,2 to 1,2-Butenoxide, taking into account that this will represent a worst case scenario.
DOW (1983) reported the fate of 1,2 -Butenoxide (BO) in male rats following inhalation exposure. The following was stated: BO is extensively metabolised and rapidly eliminated following either inhalation exposure or gavage in F344 male rats. 100, 400, 2000 ppm BO caused dose-related depletion of non-protein sulfhydryl groups in liver and kidney tissue. Conjugation of BO with GSH is an important detoxification mechanism in rodents. On the other hand, depletion of GSH is also correlated with enhanced oxidative stress and cell proliferation. Steady-state uptake rates of BO were determined to be 0.0433 mg/kg/min at 50 ppm and 0.720 mg/kg/min at 1000 ppm. These rates correspond to an estimated uptake of 15.6 and 252 mg/kg during a six hour exposure. It appears that physical and biological processes involved in absorption, metabolism and elimination of BO are essentially linear throughout the exposure range of 50 - 1000 ppm.
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