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Diss Factsheets
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EC number: 217-775-8 | CAS number: 1951-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In mouse lymphoma test using test solutions containing 200, 250, 300, 350, and 400 µ/L of Piperazine, compound with phosphoric acid, negative results were reported both with and without metabolic activation.
Based on the in-vitro bacterial reverse mutation assay test on Salmonella typhimurium strain TA 1535, TA 1537, TA 98, and TA 100 tested at the concentrations 33, 100, 333, 1,000, or 2,167 μg/plate with and without S9 metabolic activation it was found that Piperazine does not exhibit positive gene mutation effect.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Mouse lymphoma assay (test)
- GLP compliance:
- not specified
- Type of assay:
- mammalian cell gene mutation assay
- Species / strain / cell type:
- other: mouse lymphoma
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- no data
- Test concentrations with justification for top dose:
- 200, 250, 300, 350, and 400 µ/L
- Species / strain:
- other: mouse lymphoma
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):
negative
In mouse lymphoma test using test solutions containing 200, 250, 300, 350, and 400 µ/L of Piperazine, compound with phosphoric acid, negative results were reported both with and without metabolic activation - Executive summary:
In mouse lymphoma test using test solutions containing 200, 250, 300, 350, and 400 µ/L of Piperazine, compound with phosphoric acid, negative results were reported for both with and without metabolic activation Thus the substance was found to be non genotoxic.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Additional information from genetic toxicity in vitro:
The chemical Piperazine, compound with phosphoric acid, was not found to have genetic toxicity effect. The summary of the various studies used in weight of evidence that supports this fact is presented below
S. No |
Experimental system |
Effect |
Chemical |
Source |
1 |
mouse lymphoma |
Negative |
Piperazine phosphate |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis |
2 |
Chinese hamster Ovary (CHO) |
Negative |
Piperazine phosphate |
USEPA High volume program (HPV) report |
3 |
Chinese hamster Ovary (CHO) |
Negative |
Piperazine phosphate |
Danish EPA |
4 |
S. typhimurium TA 1535, TA 1537, TA 98 and TA 1 |
Negative |
Piperazine |
Environ. Mut. suppl. 1, 3-142. |
5 |
Chinese hamster Ovary (CHO) |
Negative |
Piperazine |
Report Reckitt and Colman from Huntingdon Research Centre Lt |
Justification for classification or non-classification
Based on the data available from various data sources for the target chemical piperazine, compound with phosphoric acid, as well as the read across chemical piperazine, it can be concluded that the chemical piperazine phosphate is not a genetic toxicant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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