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EC number: 231-842-9 | CAS number: 7758-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study (OECD)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Copper Monochloride CAS No: 7758-89-6
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- INCHEM 2009
- Report date:
- 2006
- Reference Type:
- other: Study cited in OECD SIDS
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Copper chloride
- EC Number:
- 231-842-9
- EC Name:
- Copper chloride
- Cas Number:
- 7758-89-6
- Molecular formula:
- Cl Cu
- IUPAC Name:
- λ¹-copper(1+) chloride
- Details on test material:
- - Name of test material (as cited in study report): Copper monochloride
- Analytical purity: 97%
- Source: Simga-Aldrich corporation
- Lot/batch No.: Lot No. 17119BO
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
no data
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: The test substance was wetted with a saline solution.
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal part
- % coverage: approximately 10 % of the total body surface area
- Type of wrap if used: porous gauze dressing covered from a non-irritating tape for 24 hours
REMOVAL OF TEST SUBSTANCE
- Washing (if done): residual test substance was removed using a saline solution
- Time after start of exposure: 24 hours
TEST MATERIAL
- For solids, paste formed: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw for males; 2000, 1500, 1000, 500 mg/kg bw for females
- No. of animals per sex per dose:
- 5 (in total: 5 males; 25 females)
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Cages of rats were checked at least once a day for any mortality. Animals were individually observed hourly during the first 4 hours after dosing with special attention, and daily for a total of 14 days. The nature and severity of the clinical signs and time were recorded at each observation.
The body weight of each rat was recorded on day 1 (prior to dosing), day 8 and day 15 (prior to necropsy). Individual body weight changes were calculated.
- Necropsy: All animals were killed on day 15 by carbon dioxide asphyxiation and subject to a gross necropsy. All gross pathological changes were recorded for each animal. Microscopic examination was not conducted because evidence of gross pathlogical changes was not showed.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 224 mg/kg bw
- 95% CL:
- 1 032 - 1 453
- Mortality:
- Males showed no death, but females showed 4 deaths in 2000 mg/kg bw, 4 deaths in 1500 mg/kg bw, and 1 death in 1000 mg/kg bw, respectively.
- Clinical signs:
- other: It was observed that symptom of the hardness of skin, an exudation of hardness site, formation of scar/falling off scar, and reddish change in application sites. It was considered to relate with application of test substance. A reddish or black urine was
- Gross pathology:
- In macroscopic examination, on application sites, the died males showed hardness of skin and acute rats showed necrosis and hemorrhage in subcutaneous. At test finished, it was observed crust of applied site in necropsyp rat. The higher dose concentration, this symptom was severely observed. It was found to be appeared inflammatory response of applied site caused by test substance and toxicity by it. Internally, no abnormality was observed in all animals. In 1500 mg/kg bw of 1 female, size of kidney, adrenal gland and spleen were enlarged and lung became smaller, but it was not considered test substance’s effect but lesion showed in rodent.
Any other information on results incl. tables
When given copper monochloride to rats by dermal application, it was found to cause skin inflammation and injury. In case of being absorbed by dermal, it was found to cause systemic toxicity symptoms. Female rats appeared to be more susceptible to copper monochloride than males based on mortality and clinical signs.
Applicant's summary and conclusion
- Conclusions:
- CL-Freetext:
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