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EC number: 248-326-4 | CAS number: 27213-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Litchfield J T& Wilcoxon F A. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:99-113, 1949
- Principles of method if other than guideline:
- Litchfield J T& Wilcoxon F A. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:99-113, 1949
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
- EC Number:
- 293-346-9
- EC Name:
- Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
- Cas Number:
- 91078-64-7
- Molecular formula:
- Not applicable (a generic molecular formula can not be provided for this specific UVCB substance)
- IUPAC Name:
- Naphthalenesulfonic acids, branched and linear Bu derivs., sodium salts
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 790 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 14 days
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 14 days
Any other information on results incl. tables
Oral administration
Administration was performed by means of a gavage.
Male rats
A.I. dose mg/kg |
Toxicological Results after 14 days |
Signs of intoxication |
Died after no. days |
|
start |
end |
|||
500 |
0/15 |
- |
- |
- |
1000 |
0/15/15 |
2h |
2d |
- |
1500 |
0/15/15 |
2h |
2d |
- |
1750 |
4/15/15 |
2h |
3d |
1-3 |
1850 |
11/15/15 |
1.5h |
2d |
1 |
2000 |
12/15/15 |
Ih |
3d |
1-2 |
2250 |
15/15/15 |
Ih |
- |
1 |
Results: DL50 (14 days) 1790 mg A.I./kg (1700-1890)
S = 1.1
Highest dose without findings: 500 mg/kg
Lowest lethal dose: 1750 mg/kg
Female rats
A.I. dose mg/kg |
Toxicological Results after 14 days |
Signs of intoxication |
Died after no. days |
|
start |
end |
|||
500 |
0/0/15 |
- |
- |
- |
1000 |
0/0/15 |
- |
- |
- |
2500 |
2/15/15 |
40' |
3d |
2 |
3000 |
5/15/15 |
15' |
5d |
1-2 |
3500 |
10/15/15 |
10' |
7d |
1 |
4000 |
11/15/15 |
8' |
7d |
1 |
4500 |
14/15/15 |
6' |
- |
1 |
5000 |
15/15/15 |
4' |
- |
1 |
Result: DL50 (14 days) 3300 mg A.I./kg (3025-3600)
S = 1.2
Highest dose without findings: 1000 mg/kg
Lowest lethal dose: 2500 mg/kg
Female rabbits
A single oral dose of 1000 mg/kg to 3 rabbits respectively did not cause any distinct signs of intoxication.
Result: DL50 (14 days) > 1000 mg A.I./kg.
Female dogs
A single oral dose of 500 mg/kg to 2 dogs caused vomiting within one hour. However, no signs of intoxication could be determined.
Signs of intoxication
The signs of intoxication (deterioration of general health, labored breathing) occurred in mice and rats within 2 hours.
These signs could be observed from 2 to 7 days. Death occurred within 1 to 3 days.
Intraperitoneal injection
The active ingredient was injected into the abdominal cavity of the animals.
Male rats
A.I. dose mg/kg |
Toxicological Results after 14 days |
Signs of intoxication |
Died after no. days |
|
start |
end |
|||
10 |
0/0/15 |
- |
- |
- |
25 |
0/15/15 |
1.5h |
Id |
—_ |
50 |
0/15/15 |
30' |
4d |
- |
100 |
0/15/15 |
20' |
5d |
- |
150 |
0/15/15 |
15' |
6d |
4 |
175 |
3/15/15 |
13' |
7d |
3-6 |
200 |
5/15/15 |
10' |
7d |
1-6 |
225 |
10/15/15 |
8' |
7d |
1-5 |
240 |
9/15/15 |
5' |
7d |
1-4 |
250 |
15/15/15 |
5' |
- |
- |
Result: DL50 (14 days) 213 mg A.I./kg (200-226)
S = 1.1
Highest dose without findings: 10 mg/kg
Lowest lethal dose: 175 mg/kg
Male mice
A.I. dose mg/kg |
Toxicological Results after 14 days |
Signs of intoxication |
Died after no. days |
|
start |
end |
|||
10 |
O/ 0/15 |
- |
- |
- |
25 |
0/15/15 |
30' |
Id |
- |
50 |
0/15/15 |
22' |
2d |
- |
100 |
1/15/15 |
10' |
5d |
4 |
150 |
8/15/15 |
5' |
7d |
2-5 |
200 |
12/15/15 |
4' |
7d |
1-6 |
250 |
14/15/15 |
3' |
- |
1-5 |
400 |
15/15/15 |
2' |
- |
1-2 |
Result: DL50 (14 days) 155.5 mg A.I. / kg (134-181)
S = 1.3
Highest dose without findings: 10 mg/kg
Lowest lethal dose: 100 mg/kg
Signs of intoxication:
Within mainly 30 minutes after the injection the animals showed signs of a deterioration of general health and labored breathing. In some cases the signs of intoxication could be observed for up to 7 days. Death occurred within 1 to 6 days.
Intravenous injectionin male mice
The active ingredient was injected into the caudal vein of mice at a rate of 1 ml/min in physiological NaCl solution.
A.I. dose mg/kg |
Toxicological Results after 14 days |
Signs of intoxication |
Died after no. days |
|
start |
end |
|||
25 |
O/ 0/15 |
- |
- |
- |
50 |
0/15/15 |
30' |
3d |
- |
75 |
1/15/15 |
25' |
3d |
2 |
85 |
6/15/15 |
17' |
6d |
2 |
100 |
12/15/15 |
13' |
7d |
2 |
150 |
15/15/15 |
5' |
- |
1-2 |
Result: DL50 (14 days) 89.1 mg A.I. / kg (84-95)
S =1.1
Highest dose without findings: 25 mg/kg
Lowest lethal dose: 75 mg/kg
The sings of intoxication were similar to those following intraperitoneal injection. Death occurred here within 2 days.
Subcutaneous application to male rats
A 500 mg/kg b.w. dose of the active ingredient was applied in 25% aqueous solution to the dorsal skin of 5 male rats shorn on the previous day. The compound was left on the skin for 7 days.
No signs of intoxication were observed in the rats treated in this manner.
Result: DL50 > 500 mg A.I. / kg.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The DL50 in male rats (14 days) 1790 mg A.I./ kg (1700-1890) and DL50 in female rats (14 days) 3300 mg A.I./ kg (3025-3600)
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