Alcohols, C7-9

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions, not carried out to GLP but subject to QA audit.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Method: other: in house protocol

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C6-12

EC Number:

271-642-9

EC Name:

Alcohols, C6-12

Cas Number:

68603-15-6

IUPAC Name:

octan-1-ol

Details on test material:

Tradename Linevol 79, C6-12 alcohols Type C

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: hell Toxicology Laboratory (Tunstall) Breeding Unit,  Sittingbourne, Kent, UK
- Age at study initiation: 11 weeks approx.
- Housing: After exposure the animals were individually housed in hanging polypropylene cages with stainless steel wire mesh floor and top. They were mounted in rows of four, with forty cages on each double sided rack.
- Diet: rat food, ad libitum
- Water: filtered but untreated water, ad libitum



ENVIRONMENTAL CONDITIONS
- Temperature (°C): ca. 20
- Humidity (%): ca. 55
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12

IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

other: atmosphere generated as a mist

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 7 litres
- Method of holding animals in test chamber: stainless steel mesh carriers
- Source and rate of air: the test atmosphere was apssed through each of the chambers at minimal flow rate of 10 l/min
- System of generating particulates/aerosols: The test atmosphere was generated as a mist using a Sonicore ultrasonic atomiser fitted with a number 035 nozzle. The test substance was supplied to the atomiser at a constant flow rate using a pressure pump and the compressed air was supplied through a Fisher pressure controller.
- Method of particle size determination: The particle size distribution was determined using a Casella four stage impactor.


TEST ATMOSPHERE
- Brief description of analytical method used: the test atmosphere was analysed gravimetrically throughout the exposure period in consecutive periods in 30 min.



TEST ATMOSPHERE (if not tabulated)
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 3.4 um / 1.5

Duration of exposure:

4 h

Concentrations:

0.58 mg/l

No. of animals per sex per dose:

5M, 5F

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs observed throughout exposure and daily thereafter throughout the 14 day observation period. Initial and terminal  bodyweights were recorded.
- Necropsy of survivors performed: yes/no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.58 mg/L air

Exp. duration:

4 h

Mortality:

There were no mortalities.

Clinical signs:

other: During the exposure period 50% of the rats salivated and  a red nasal discharge was observed. These signs had disappeared by the  following day. 

Body weight:

 Body weight data was not reported.

Gross pathology:

Not carried out.

Other findings:

None reported.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The rat 4 hour LC50 for a mist of Linevol 79 is >0.58 mg/l. Signs of intoxication were transient and confined to salivation and red nasal discharge in some rats during exposure.