Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-219-8 | CAS number: 634-93-5
Carcinogenicity
Administrative data
Description of key information
Weisburger 1978: A statistically significant increase in vascular tumours was observed in male mice. Hepatocellular carcinomas were also increased in male mice, but not in a dose-related manner. No observations of tumours were reported for female mice.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Study duration:
- chronic
- Species:
- mouse
- Quality of whole database:
- The quality of the database was very low.
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data is not considered to be reliable, or adequate for classification purposes.
The classification for this endpoint is inconclusive.
Additional information
The study indicates the test substance is not a potent carcinogen in the strain/sexes at the dose levels used; however, there is insufficient information to conclude that the data are robust. A full assessment of the carcinogenicity potential is not possible for the following reasons:
· Overall the study is considered unreliable due to the lack of reported experimental details (rated Klimisch 3).
· Data are not available on a full compliant of the regulatory species/sex (female rats).
· Limited data are presented within the report.
· The substance was not found to be positive in genotoxicity studies.
· The report did not make a clear position on the relation of tumours with treatment.
The available data is not considered to be reliable, or adequate for classification purposes.
Justification for selection of carcinogenicity via oral route endpoint:
None of the available data is considered to be reliable, or adequate for classification purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
