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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Description of key information

There are no in vivo data available.
Epiderm: does not show a skin irritation potential (BASF SE, 2012)
BCOP: does not cause serious eye damage (BASF SE, 2012)
Epiocular: not irritant (BASF SE, 2013)

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation

The potential of Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid to cause dermal corrosion/irritation was assessed by a single topical application of 50 μL (corrosion test) or 30 μL (irritation test) of the undiluted test substance to a reconstructed three dimensional human epidermis model (EpiDerm™) OECD guideline 431/439. For the corrosion test two EpiDerm™ tissue samples were incubated with the test substance for 3 minutes and 1 hour, respectively.

Based on the observed results it was concluded, that Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react.

prod. with acrylic acid does not show a skin irritation potential in the EpiDerm™ skin corrosion/irritation test under the test conditions chosen. (BASF SE, 2012)

Eye irritation

The potential of Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid to cause serious damage to the eyes was assessed by a single topical application of 750 μL of the undiluted test substance to the epithelial surface of

isolated bovine corneas.

Three corneas were treated with the test substance for 10 minutes followed by a 2-hours post-incubation period.

Based on the observed results it was concluded, that Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane,

react. prod. with acrylic acid does not cause serious eye damage in the Bovine Corneal Opacity and Permeability Test (BCOP Test)

The result does not exclude an irritation potential of the test substance. (BASF SE, 2012)

The potential of Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid

to cause ocular irritation was assessed by a single topical application of 50 µL of the undiluted test substance to a reconstructed three dimensional human cornea model (EpiOcular™). Two EpiOcular™ tissue samples were incubated with the test substance for 30 minutes followed by a 2-hours post-incubation period. The mean viability of the test-substance treated tissues was 99%. Based on the observed results it was concluded, that Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acidis not irritant in the EpiOcular™ eye irritation test under the test conditions chosen (BASF SE, 2013).

Based on the results of the EpiOcular™ and the BCOP Test it was concluded, that Pentaerythritol, olig. react. prod. with 1-chloro-2,3-epoxypropane, react. prod. with acrylic acid does not show an eye irritation potential and does not cause serious eye damage under the test conditions chosen.

Respiratiory irritation

No data available.

Justification for classification or non-classification

EU classification according to Annex VI of the Directive 67/548/EEC: no classification required

GHS classification (GHS UN rev.3, 2009): no calssification required