Registration Dossier
Registration Dossier
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EC number: 208-031-3 | CAS number: 506-30-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid
- Year:
- 1 987
- Bibliographic source:
- Journal of the American College of Toxicology.(Mary Ann Liebert,Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.Volume(issue)/page/year: 6(3),321,1987
- Reference Type:
- review article or handbook
- Title:
- RTECS NUMBER : QH4375000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.Discontinued.Volume(issue)/page/year: 6(3),321,1987
Materials and methods
- Principles of method if other than guideline:
- Standard Draize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Myristic acid
- EC Number:
- 208-875-2
- EC Name:
- Myristic acid
- Cas Number:
- 544-63-8
- IUPAC Name:
- myristic acid
- Details on test material:
- - Name of test material (as cited in study report):Myristic acid
- Molecular formula :C14H28O2
- Substance type:Organic
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: Mildly irritating to the eyes of rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- other: mild irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Eye irritation tests performed by the method of Standard Draize test,100 mg of Myristic acid applied to the eyes of rabbits,resulted in a mild irritation effect." The substance Myristic acid is thus considered "mildly irritating."
- Executive summary:
Eye irritation tests performed by the method of Standard Draize test,100 mg of Myristic acid applied to the eyes of rabbits,resulted in a mild irritation effect." The substance Myristic acid is thus considered "mildly irritating."
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