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EC number: 202-046-9 | CAS number: 91-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Decahydronaphthalene caused irreversible skin damage upon 4 h exposure. No skin necrosis was noted upon exposure for 3 min (open) or 1 h (semi-occlusive) (Hüls AG, 1989).
Only mild and reversible eye irritation was noted in an in vivo eye irritation test according to OECD 405 (Hüls AG, 1989).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-08-22 to 1989-12-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: Small white Russian, Chbb-SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Strain: Small white Russian, Chbb-SPF
- Source: Dr. Karl Thomae GmbH, Biberach (Germany)
- Sex: male
- Weight at study initiation: 2.2 - 2.5 kg
- Housing: individually in steinless steel cages
- Food (ad libitum): K4 Alleindiät für Kaninchen, Ssniff Spezialfutter GmbH, 4770 Soest
- Water (ad libitum): tap water
- preparation of testing site 24 h before treatment (shaving, 10 x 10 cm)
ENVIRONMENTAL CONDITIONS:
- Temperature: 20 °C +/- 1 °C
- Humidity: 60 % +/- 5%
- Air changes: 15/ h
- Photoperiod: 12 h dark/ 12 h light - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 1, 24, 48, 72 hours, 6, 8, 10, and 14 days after patch removal
- Number of animals:
- 3
- Details on study design:
- ADMINISTRATION/EXPOSURE
- Area of exposure: 6 cm²
- Total volume applied: 0.5 ml
- Occlusion: mull patch, elastic dressing
- Removal of test substance: washing with warm water
- Additional tests with 1 animal each: 3 minutes open application, 1 hour semiocclusive application
- Post exposure period: 14 days
EXAMINATIONS
- Examination time points: 1, 24, 48, 72 hours, 6, 8, 10, and 14 days after patch removal; evaluation based on readings 1-4
- Scoring system: OECD Guideline; evaluation: VCI notes on safety data sheet and Appendix VI of 79/831/EEC - Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 7.5
- Max. score:
- 8
- Reversibility:
- not reversible
- Remarks on result:
- other: Eschar formation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- AVERAGE SCORE
- Erythema: 4.00
- Edema: 3.33
REVERSIBILITY: Not reversible. Eschar detached and new skin within 14 days.
OTHER EFFECTS: After a 3-min open application or a 1-hour semiocclusive application no necrosis was observed. - Conclusions:
- In this primary dermal irritation study, the test item was corrosive to the rabbit skin.
- Executive summary:
In a primary dermal irritation study 3 Small White Russian, Chbb-SPF rabbits were dermally exposed to 0.5 ml of undiluted test item for 4 hours to the shaved back skin. Animals then were observed for 14 days. The formation of necroses was noted, the irritation index was 7.5/8. No necrosis was noted upon exposure duration of 3 min or 1 h. In this study, the test item was corrosive to the rabbit skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-09-05 to 1989-09-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: Small white Russian, Chbb-SPF
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS:
- Strain: Small white Russian, Chbb-SPF
- Source: Dr. Karl Thomae GmbH, Biberach (Germany)
- Sex: male
- Weight at study initiation: 2.2 - 2.5 kg
- Controls: untreated eye
- Housing: individually in stainless steel cages
- Diet (ad libitum): K4 Alleindiät für Kaninchen, Ssniff Spezialfutter GmbH, 4770 Soest
- Water (ad libitum): tap water
ENVIRONMENTAL CONDITIONS:
- Temperature: 20°C +/- 1°C
- Humidity: 60 % +/- 5 %
- Air change: 15/ h
- Photoperiods: 12 h dark/ 12 h light - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 72 hour(s)
- Observation period (in vivo):
- 10 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- ADMINISTRATION/EXPOSURE
- Vehicle: none
- tested for cornea damage with sodium flourescein solution and eye lamp
- rinsed after 72 h with saline solution
- Postexposure observation period: 10 days
EXAMINATIONS
- Ophtalmoscopic examination: 1, 24, 48, 72 hours, 6, 8, and 10 days after treatment
- Tool used to assess score: sodium fluorescein / ophthalmic lamp / visual inspections
- Scoring system: Draize (1959); evaluation: VCI notes on safety data sheet and Appendix VI of 79/831/EEC - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- other: conjunctivae redness
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 0.78
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0.44
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 0-8 days
- Score:
- 3.5
- Max. score:
- 110
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- AVERAGE SCORE
- Cornea: 0.0
- Iris: 0.0
- Conjunctivae (Redness): 0.78
- Conjunctivae (Chemosis): 0.44
- Overall irritation score: 3.5/110
DESCRIPTION OF LESIONS: redness, swelling, and slight incrustation of eyelids
REVERSIBILITY: complete within 8 days except for slight redness of eyelids in one animal - Conclusions:
- In a primary eye irritation study decahydronaphthalene is considered to be not irritating to eyes.
- Executive summary:
In a primary eye irritation study 0.1 mL decahydronaphthalene were administered into the conjunctival sac of three male rabbits.
Slight reversible irritation was noted.
Eye irritation index was assessed using Draize scale.
The test was evaluated as follows (average of evaluation at 24, 48 and 72 hours respectively): cornea: 0, iris: 0, conjunctivae: redness: 0.78 and chemosis: 0.44 (mean scores on Draize scale). Therefore, decahydronaphthalene is considered to be not irritating to eyes with an overall irritation index of 3.5/110 (0 - 10 = not irritating).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the in vivo data, the test item is classified as corrosive according to CLP regulation 1272/2008 (Cat 1C, H314; Causes severe skin burns and eye damage).
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