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EC number: 401-680-5 | CAS number: 125304-04-3 TINUVIN 171; TINUVIN 571
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 31.01. - 23.02.2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study, with acceptable restrictions, performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for Testing of Chemicals. Draft proposal for a New Guideline: "Acute Dermal Photoirritation Dose-Response Test", February 1995.
- Qualifier:
- according to guideline
- Guideline:
- other: CTFA Safety Testing Guidelines, The Cosmetic, Toiletry and Fragrance Association, Inc. Washington, D.C. 20036; "Guidelines for Evaluating Photodermatitis:, 1991.
- Type of method:
- in vivo
Test material
- Reference substance name:
- A mixture of: isomers of 2-(2H-benzotriazol-2-yl)-4-methyl-(n)-dodecylphenol; isomers of 2-(2H-benzotriazol-2-yl)-4-methyl-(n)-tetracosylphenol; isomers of 2-(2H-benzotriazol-2-yl)-4-methyl-5,6-didodecyl-phenol. n=5 or 6
- EC Number:
- 401-680-5
- EC Name:
- A mixture of: isomers of 2-(2H-benzotriazol-2-yl)-4-methyl-(n)-dodecylphenol; isomers of 2-(2H-benzotriazol-2-yl)-4-methyl-(n)-tetracosylphenol; isomers of 2-(2H-benzotriazol-2-yl)-4-methyl-5,6-didodecyl-phenol. n=5 or 6
- Cas Number:
- 125304-04-3
- Molecular formula:
- C25 H35 N3 O and C37 H59 N3 O
- IUPAC Name:
- Reaction mass of 2-(2H-benzotriazol-2-yl)-4-methyl-(n)-dodecylphenol, branched and 2-(2H-benzotriazol-2-yl)-4-methyl-5,6-didodecyl-phenol, branched
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals in Boyertown, Pennsylvania
- Age at study initiation: 4 - 6 weeks
- Weight at study initiation: appr. 300 - 450 grams
- Housing: in stainless steel cages
- Diet: Lab Diet Certified Guinea Pig Diet #5026 ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 29
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- petrolatum
- Remarks:
- for challenge; unchanged during induction
- Frequency of treatment:
- 5 dermal induction treatments, days 1, 3,6, 8 and 10
1 challenge treatment on day 21
- No. of animals per sex per dose:
- 20 test group animals, 10 control animals
Positive control: 10 test and 5 control animals. - Control animals:
- yes
Examinations
- Examinations:
- Skin reactions were evaluated 24, 48 and 2 hours after challegenge.
- Positive control:
- Positive control was performed with 3,3',4',5-Tetrachlorosalicylanilid.
Concentrations: 7.5% during induction, 7.5, 5 & 2.5% during challenge. Vehicle = ethanol
Results and discussion
- Details on results:
- This test item was not a photoallergen in guinea pigs, under the conditions of this test.
Any other information on results incl. tables
The positive conrol substance resulted in sensitization and is therefore a photoallergen in guinea pigs, under the conditions of this test.
Applicant's summary and conclusion
- Executive summary:
Twenty Hartley-strain guinea pigs, male, 388 - 472 g, were used as a test group. Each test group animal received injections of an adjuvant and then five induction treatments over a period of two consecutive weeks. Each induction treatment consisted of a dosage of the test item followed by an exposure of the animals to UVB irradiation and UV-A irradiation. Eleven days after the last induction application, the animals were challenged. Three concentrations of the test item and/or the vehicle were applied to each animal so that each concentration was applied to one site on each side of each animal. One site dosed with each concentration was then exposed to approximately 10 joules/cm² of UV-A irradiation. The remaining site dosed with each concentration was not exposed to the UV-A. Ten similar animals, 418 - 468 g, were utilized as a control group. They were treated with the adjuvant but received no exposure to the test article or UV irradiation until the challenge phase, when they received the same challenge treatment as the test group animals. Induction sites were evaluated prior to each treatment. Challenge sites were evaluated 24, 48 and 72 hours following irradiation.The test item was used as received for the induction dosages and in petrolatum suspensions at challenge.
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