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EC number: 401-680-5 | CAS number: 125304-04-3 TINUVIN 171; TINUVIN 571
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.01. - 27.02.1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, study was conducted under GLP like quality assurance.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- adopted 1984
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: samples for analysis were taken at 0h and 96h exposure.
- Sample storage conditions before analysis: not specified - Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Calculated amounts of stock solution to produce the desired test concentrations were given into the water and honogeneously distributed. The fishes were then transfered into the aquaria.
- Controls:Blank : Water
Vehicle :
- Chemical name of vehicle: Tetrahydrofuran
- Concentration of vehicle in test medium: 887 mg/L (in the concentration used for the highest test concentration)
- Evidence of undissolved material: At concentrations >100 mg/L the test substance precipitated immediately. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Source: West-Aquariun, D-3422 Bad Lauterberg, Germany
- Length at study initiation: 22 mm (20 - 25 mm), mean value based on 10 fishes
- Weight at study initiation: 0.07g (0.05 - 0.1g), mean value based on 10 fishes
- Feeding during test: none
ACCLIMATION
- Acclimation period: 25 days
- Acclimation conditions (same as test or not): yes, same - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 194 mg CaCO3/L
- Test temperature:
- 23 °C within +/- 1 °C
- pH:
- between 7.7 and 8.1
- Dissolved oxygen:
- between 86 mg/L and 101 mg/L
- Nominal and measured concentrations:
- nominal: 10, 18, 32, 58, 100 mg/L
measured (0 h): 8.3, 13.7, 27.4, 49.7, 86.9 mg/L
measured (72 h): 9.6, 15.3, 19.8, 48.8, 72.3 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria of 20 L filled with 15 L (36/22/25 cm)
- Aeration: none
- No. of organisms per vessel: 10 per concentration and control. 10 per aquarium.
- Biomass loading rate: 0.05 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water (carbon filter)
- Intervals of water quality measurement: The oxygen content, pH and temperature were measured at 0, 24, 48, 72 and 96 hours.
OTHER TEST CONDITIONS
- Photoperiod: Fluorescent light, 16 hours daily
EFFECT PARAMETERS MEASURED:
Mortalities were recorded after 24, 48, 72 and 96 hours exposure. The fishes were examined daily for symptoms of toxicity. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 72.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 72.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: no symptoms
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no symptoms
- Any observations that might cause a difference between measured and nominal values: At concentrations of 100 mg/L the test item precipitated immediately. - Reported statistics and error estimates:
- None.
Reference
Description of key information
There is a high probability that the product is not acutely harmful to fish.
Key value for chemical safety assessment
Additional information
In a 96-h acute toxicity study, zebra-fish (Brachydanio rerio) were exposed to test item at nominal concentrations of 0 (control, solvent control) and 100 mg/L under static conditions. The 96-h LC50 was > 100 mg/L. The NOEC, based on mortality and sublethal effects, were ≥ 100 mg/L, respectively. Sublethal effects were not observed. It can be concluded that the test substance is not acutely toxic to fish at the range of solubility.
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