acetalization product between glucose and C16-18(even numbered)- alcohol

Toxicity to birds

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to birds

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Description of key information

According the guidance R. 7c, the exposure of birds is generally only considered for the fish and earthworm food chains following the release of a substance via a sewage treatment works. 

Since the substance is readily biodegradable and adsorbable, it will be almost completely eliminated in STP and exposure of the soil compartment may be considered negligible. In addition, as the substance is highly insoluble in water, exposure of the aquatic compartment and bioaccumulation in aquatic species is unlikely. 

Therefore, the exposure of birds via fish and earthworm food chains is unlikely. 

Furthermore, with regard to metabolic pathways of alkyls polyglucosides and fatty alcohols, it is anticipated that alkyl polyglycosides are 100% absorbed by oral ingestion, followed by ready hydrolysis and metabolism of the resulting cleavage products, sugar and fatty alcohol, in common mammalian physiological pathways. And long chained alcohols are generally highly efficiently metabolised and there is limited potential for retention or bioaccumulation for the parent alcohols and their biotransformation products (see section 7.1).

Concerning the toxicity potential of the substance to bird, not expected to impair fertility based on the weight of evidence approach using data from reproductive screening studies (octadecan-1-ol, APG C12-14) a fertility study (C22 – docosan-1-ol) together with a lack of effect on the reproductive organs in repeat dose studies (C22 – docosan-1-ol, hexadecan-1-ol, registered substance).

To conclude, a long-term or reproductive toxicity to birds are not necessary due to the not expected exposure of birds via fish and earthworm foods chains, the metabolic pathways of registered substance and the evidence of not expected repro-toxicity and no significant adverse effect related to the substance observed in the repeated dose toxicity studies available effect of registered substance.