Registration Dossier
Registration Dossier
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EC number: 231-728-9 | CAS number: 7705-07-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented. Data is suitable for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the design of animal tests for the corrosiveness of industrial chemicals
- Author:
- Potokar M, Grundler OJ, Heusener A, Jung R, Mürmann P, Schöbel C, Suberg H, Zechel HJ
- Year:
- 1 985
- Bibliographic source:
- Fd. Chem. Toxic. 23(6): 615-617
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (adopted 2002)
- Deviations:
- yes
- Remarks:
- (6 animals were tested, local reactions were examined after 1 and 4 h, occlusive and semi-occlusive dressing was used)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Titanium tetrachloride
- EC Number:
- 231-441-9
- EC Name:
- Titanium tetrachloride
- Cas Number:
- 7550-45-0
- IUPAC Name:
- titanium tetrachloride
- Details on test material:
- - Name of test material (as cited in study report): Titanium tetrachloride
- Analytical purity: No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Various breeders, not specified
- Weight at study initiation: 2-4 kg
- Housing: Individually
- Diet: Ad libitum (except during exposure), standard rabbit feed
- Water: Ad libitum (except during exposure)
ENVIRONMENTAL CONDITIONS
Standardised laboratory conditions, no further data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 1 and 4 hours
- Observation period:
- 7 days
- Number of animals:
- 6 for each exposure time
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal and lateral parts of the trunk
- % coverage: Unspecified, gauze pads with 3x3 cm were used
- Type of wrap if used: Air permeable circular bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Rinsed with water and dried
- Time after start of exposure: Either after 1 or 4 hours
SCORING SYSTEM: As described in the OECD guideline 404
Results and discussion
In vivo
Results
- Irritation parameter:
- other: full thickness destruction
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: 1 h
- Reversibility:
- not reversible
- Remarks on result:
- other: Score n.a.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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