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EC number: 271-178-7 | CAS number: 68516-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Prediction of ready biodegradability based on six QSAR models
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Duration of test (contact time):
- 28 d
- Parameter:
- other: biodegradation
- Sampling time:
- 28 d
- Remarks on result:
- other: Result: not readily biodegradable
- Interpretation of results:
- not readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable method, meets basic scientific principles
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Estimation of results of OECD screening tests on ready biodegradation in water: CATALOGIC (v5.11.5) BOD 28 days MITI (OECD 301C) v06.07
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 0.48
- Sampling time:
- 28 d
- Details on results:
- Model domain similarity:
- Parametric domain: 100%
- Structural domain: 20.69% (79.31% unknown)
- Mechanistic domain: 100% - Interpretation of results:
- not readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable method, meets basic scientific principles
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Estimation of results of OECD screening tests on ready biodegradation in water: CATALOGIC (v5.11.5) BOD 28 days MITI (OECD 301C) v06.07
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 0.44
- Sampling time:
- 28 d
- Details on results:
- Model domain similarity:
- Parametric domain: 100%
- Structural domain: 29.03% (70.97% unknown)
- Mechanistic domain: 100% - Interpretation of results:
- not readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Prediction of ready biodegradability based on six QSAR models
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Duration of test (contact time):
- 28 d
- Parameter:
- other: biodegradation
- Sampling time:
- 28 d
- Remarks on result:
- other: Result: not readily biodegradable
- Interpretation of results:
- not readily biodegradable
Referenceopen allclose all
Summary:
Biowin1 (Linear Model Prediction) : Does Not Biodegrades Fast
Biowin2 (Non-Linear Model Prediction): Does Not Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Recalcitrant
Biowin4 (Primary Biodegradation Timeframe): Weeks-Months
Biowin5 (MITI Linear Model Prediction) : Does Not Biodegrade Fast
Biowin6 (MITI Non-Linear Model Prediction): Does Not Biodegrade Fast
Biowin7 (Anaerobic Model Prediction): Does Not Biodegrades Fast
Ready Biodegradability Prediction: NO
Results of individual models (Biowin1 to Biowin7):
Type |
Num |
Biowin1 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.1158 |
0.2316 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.2102 |
0.4203 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.1824 |
-0.7297 |
Frag |
2 |
Azo group [-N=N-] |
-0.2418 |
-0.4837 |
MolWt |
* |
Molecular Weight Parameter |
-0.4021 |
|
Const |
* |
Equation Constant |
0.7475 |
|
Result |
Biowin1 (Linear Biodeg Probability) |
-0.2159 |
Type |
Num |
Biowin2 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.9086 |
1.8172 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
2.6913 |
5.3826 |
Frag |
4 |
Aromatic chloride [-CL] | -2.0155 |
-8.0620 |
Frag |
2 |
Azo group [-N=N-] | -8.2194 | -16.4388 |
MolWt |
* |
Molecular Weight Parameter |
-11.9926 |
|
Result |
Biowin2 (Non-Linear Biodeg Probability) |
0.0000 |
A probability greater than or equal to 0.5 indicates --> biodegrades fast
A probability less than 0.5 indicates --> does not biodegrade fast
Type |
Num |
Biowin3 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.0564 |
0.1128 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
-0.0542 |
-0.1084 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.2066 |
-0.8264 |
Frag |
2 |
Azo group [-N=N-] | -0.3004 |
-0.6007 |
MolWt |
* |
Molecular Weight Parameter |
-1.8663 |
|
Const |
* |
Equation Constant |
3.1992 |
|
Result |
Biowin3 (Survey Model - Ultimate Biodeg) |
-0.0899 |
Type |
Num |
Biowin4 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.0397 |
0.0794 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.2054 |
0.4109 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.1653 |
-0.6614 |
Frag |
2 |
Azo group [-N=N-] | -0.0528 |
-0.1056 |
MolWt |
* |
Molecular Weight Parameter |
-1.2185 |
|
Const |
* |
Equation Constant |
3.8477 |
|
Result |
Biowin4 (Survey Model - Primary Biodeg) |
2.3526 |
Result classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(primary & ultimate) 2.00 -> months 1.00 -> longer
Type |
Num |
Biowin5 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.0642 |
0.1285 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.1266 |
0.2533 |
Frag |
4 |
Aromatic chloride [-CL] |
0.0062 |
0.0247 |
Frag |
2 |
Azo group [-N=N-] |
-0.0459 |
-0.0917 |
Frag |
22 |
Aromatic-H |
0.0082 |
0.1808 |
MolWt |
* |
Molecular Weight Parameter |
|
-2.5125 |
Const |
* |
Equation Constant |
|
0.7121 |
Result |
Biowin5 (MITI Linear Biodeg Probability) |
-1.3049 |
Type |
Num |
Biowin6 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.4884 |
0.9768 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.8859 |
1.7717 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.2191 |
-0.8766 |
Frag |
2 |
Azo group [-N=N-] |
-10.6129 |
-21.2258 |
Frag |
22 |
Aromatic-H |
0.1201 |
2.6431 |
MolWt |
* |
Molecular Weight Parameter |
|
-24.3810 |
Result |
Biowin6 (MITI Non-Linear Biodeg Probability) |
0.0000 |
A probability greater than or equal to 0.5 indicates --> readily degradable
A probability less than 0.5 indicates --> not readily degradable
Type |
Num |
Biowin7 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.0807 |
0.1614 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
-0.5679 |
-1.1358 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.4023 |
-1.6091 |
Frag |
2 |
Azo group [-N=N-] |
0.0000 |
0.0000 |
Frag |
22 |
Aromatic-H |
-0.0954 |
-2.0995 |
Const |
* |
Equation Constant |
0.8361 |
|
Result |
Biowin7 (Anaerobic Linear Biodeg Prob) |
-3.8468 |
A probability greater than or equal to 0.5 indicates --> biodegrades fast
A probability less than 0.5 indicates --> does not biodegrade fast
Summary:
Biowin1 (Linear Model Prediction) : Does Not Biodegrades Fast
Biowin2 (Non-Linear Model Prediction): Does Not Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Recalcitrant
Biowin4 (Primary Biodegradation Timeframe): Weeks-Months
Biowin5 (MITI Linear Model Prediction) : Does Not Biodegrade Fast
Biowin6 (MITI Non-Linear Model Prediction): Does Not Biodegrade Fast
Biowin7 (Anaerobic Model Prediction): Does Not Biodegrades Fast
Ready Biodegradability Prediction: NO
Results of individual models (Biowin1 to Biowin7):
Type |
Num |
Biowin1 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.1158 |
0.2316 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.2102 |
0.4203 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.1824 |
-0.7297 |
Frag |
2 |
Azo group [-N=N-] |
-0.2418 |
-0.4837 |
Frag |
2 |
Trifluoromethyl group [-CF3] |
-0.5204 |
-1.0408 |
MolWt |
* |
Molecular Weight Parameter |
-0.4430 |
|
Const |
* |
Equation Constant |
0.7475 |
|
Result |
Biowin1 (Linear Biodeg Probability) |
-1.2977 |
Type |
Num |
Biowin2 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.9086 |
1.8172 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
2.6913 |
5.3826 |
Frag |
4 |
Aromatic chloride [-CL] |
-2.0155 |
-8.0620 |
Frag |
2 |
Azo group [-N=N-] |
-8.2194 |
-16.4388 |
Frag |
2 |
Trifluoromethyl group [-CF3] |
-5.6696 |
-11.3392 |
MolWt |
* |
Molecular Weight Parameter |
|
-13.2129 |
Result |
Biowin2 (Non-Linear Biodeg Probability) |
0.0000 |
A probability greater than or equal to 0.5 indicates --> biodegrades fast
A probability less than 0.5 indicates --> does not biodegrade fast
Type |
Num |
Biowin3 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.0564 |
0.1128 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
-0.0542 |
-0.1084 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.2066 |
-0.8264 |
Frag |
2 |
Azo group [-N=N-] |
-0.3004 |
-0.6007 |
Frag |
2 |
Trifluoromethyl group [-CF3] |
-0.5130 |
-1.0259 |
MolWt |
* |
Molecular Weight Parameter |
|
-2.0562 |
Const |
* |
Equation Constant |
|
3.1992 |
Result |
Biowin3 (Survey Model - Ultimate Biodeg) |
-1.3058 |
Type |
Num |
Biowin4 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.0397 |
0.0794 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.2054 |
0.4109 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.1653 |
-0.6614 |
Frag |
2 |
Azo group [-N=N-] |
-0.0528 |
-0.1056 |
Frag |
2 |
Trifluoromethyl group [-CF3] |
-0.2744 |
-0.5488 |
MolWt |
* |
Molecular Weight Parameter |
|
-1.3425 |
Const |
* |
Equation Constant |
|
3.8477 |
Result |
Biowin4 (Survey Model - Primary Biodeg) |
1.6798 |
Result classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(primary & ultimate) 2.00 -> months 1.00 -> longer
Type |
Num |
Biowin5 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.0642 |
0.1285 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.1266 |
0.2533 |
Frag |
4 |
Aromatic chloride [-CL] |
0.0062 |
0.0247 |
Frag |
2 |
Azo group [-N=N-] |
-0.0459 |
-0.0917 |
Frag |
6 |
Fluorine [-F] |
0.0174 |
0.1043 |
Frag |
18 |
Aromatic-H |
0.0082 |
0.1479 |
MolWt |
* |
Molecular Weight Parameter |
|
-2.7682 |
Const |
* |
Equation Constant |
|
0.7121 |
Result |
Biowin5 (MITI Linear Biodeg Probability) |
-1.4892 |
Type |
Num |
Biowin6 Fragment description |
Coeff |
Value |
Frag |
2 |
Aromatic alcohol [-OH] |
0.4884 |
0.9768 |
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
0.8859 |
1.7717 |
Frag |
4 |
Aromatic chloride [-CL] |
-0.2191 |
-0.8766 |
Frag |
2 |
Azo group [-N=N-] |
-10.6129 |
-21.2258 |
Frag |
6 |
Fluorine [-F] |
-3.9878 |
-23.9271 |
Frag |
18 |
Aromatic-H |
0.1201 |
2.1625 |
MolWt |
* |
Molecular Weight Parameter |
|
-26.8619 |
Result |
Biowin6 (MITI Non-Linear Biodeg Probability) |
0.0000 |
A probability greater than or equal to 0.5 indicates --> readily degradable
A probability less than 0.5 indicates --> not readily degradable
Type |
Num |
Biowin7 Fragment description |
Coeff |
Value |
|
Frag |
2 |
Aromatic alcohol [-OH] |
0.0807 |
0.1614 |
|
Frag |
2 |
Amide [-C(=O)-N or -C(=S)-N] |
-0.5679 |
-1.1358 |
|
Frag |
4 |
Aromatic chloride [-CL] |
-0.4023 |
-1.6091 |
|
Frag |
2 |
Azo group [-N=N-] |
0.0000 |
0.0000 |
|
Frag |
2 |
Trifluoromethyl group [-CF3] |
0.0000 |
0.0000 |
|
Frag |
6 |
Fluorine [-F] |
0.0000 |
0.0000 |
|
Frag |
18 |
Aromatic-H |
-0.0954 |
-1.7177 |
|
Const |
* |
Equation Constant |
0.8361 |
||
Result |
Biowin7 (MITI Non-Linear Biodeg Probability) |
-3.4651 |
A probability greater than or equal to 0.5 indicates --> biodegrades fast
A probability less than 0.5 indicates --> does not biodegrade fast
Description of key information
Not readily biodegradable (according to OECD criteria).
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
Data on the ready biodegradability of the described substance are not available. However, two model calculations were conducted to assess the biodegradability in a weight of evidence. The EPI Suite v4.10 (BIOWIN Program v4.10) calculation resulted in "not readily biodegradable". Additionally, the biodegradation was calculated by using CATALOGIC v5.11.5 (BOD 28 days MITI (OECD 301C) v06.07). It resulted in ca. 0.48 % biodegradation after 28 d. Even though the structural domain was correct with only 20.69 % (79.31 % unknown) the results support the overall conclusion in the weight of evidence.
Moreover, the 'red disazo pigment' is practically insoluble and therefore considered to be essentially not bioavailable. Due to the large molecular size, cellular uptake of the pigment is unlikely. Hence intracellular biodegradation, which is the main degradation route of bacteria, is probably low. It can be concluded that the substance is likely to persist in the environment. For this reason no ready or inherent degradation studies are proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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