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EC number: 211-662-7 | CAS number: 682-11-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April - May 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No indication of guideline followed of GLP compliance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was applied to a clipped area on rabbits for a 24 hour exposure period and was observed for 14 days to determine the toxicity of the test substance when applied dermally.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trimethylolpropane Monoallyl Ether
- IUPAC Name:
- Trimethylolpropane Monoallyl Ether
- Details on test material:
- Trimethylolpropane Monoallyl Ether was a viscous, clear, colourless liquid.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other:
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Groups of 4 male albino rabbits were used. The rabbits weighed 2 - 3 kgs.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The fur of the rabbits was clipped over the entire trunk, which equated to approximately 10% of the body surface and this area was coverd by an impervious plastic film. The calculated dose of the undiluted chemical was introduced through a cathether once the plastic cover was in place. The maximum dose applied to the rabbits was 20 milliliters/kg bw.
Following application of the test material, the rabbits were confined in stocks for 24 hours, after which the cover and the chemical were removed and the skin examined for gross changes. - Duration of exposure:
- 24 hours.
- Doses:
- 3.95, 7.5 and 15.8 g/kg.
- No. of animals per sex per dose:
- 4 male rabbits per dose group.
- Control animals:
- not specified
- Details on study design:
- Male albino rabbits (4 per dose group) were exposed to Trimethylolpropane Monoallyl Ether via dermal penetration. The degree of penetration through the intact skin was estimated employing the one-day cuff method used by Draize and associates as modified by Smyth and associates. The fur was clipped from the entire trunk of each animal and the test material was held in contact with the skin for 24 hours by an occlusive dressing. Following this exposure period, the dressing and test material were removed and the skin examined for any signs of gross changes. Mortality due to the effect of the chemical was considered complete after 14 days. All fatalities were subjected to autopsies to exclude extraneous causes of death while some survivors were sacrificed and examined for the existence of gross lesions.
- Statistics:
- No information provided.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 15.8 other: g/kg.
- Based on:
- test mat.
- Mortality:
- There were no mortalities observed in this study.
- Clinical signs:
- other: When dosed at 15.8 g/kg, necrosis of the skin was observed.
- Gross pathology:
- No information provided.
- Other findings:
- No additional information.
Any other information on results incl. tables
Skin penetration Toxicity for Rabbits of Trimethylolpropane Monoallyl Ether.
Average Weight (kg) |
|
|
||
Dosage g/kg |
Initial |
Change 14 days |
Number Died / Number Dosed |
Days after dosing on which death occurred. |
3.98 |
2.26 |
+0.33 |
0/4 |
- |
7.95 |
2.04 |
+0.51 |
0/4 |
- |
15.8 |
2.04 |
+0.07 |
0/4 |
- |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of Trimethylolpropane Monoallyl Ether by skin penetration for male albino rabbits is greater than 15.8 g/kg.
- Executive summary:
The acute dermal toxicity of Trimethylolpropane Monoallyl Ether was determined in a study conducted on groups of 4 male albino rabbits administered the test material via dermal application. The fur was clipped from the entire trunk of each test animal and Trimethylolpropane Monoallyl Ether was applied by a cathether at concentrations of 3.98, 7.95 and 15.8 g/kg to the clipped area and was held in place using an impervious plastic cover. The test material remained in place for 24 hours. Any signs of toxicity were observed on removal of the test material and further observations were made over a 14 day observation period.
No mortalities were observed at any concentration over the course of the study. When dosed at 15.8 g/kg, some skin necrosis was observed. The LD50of Trimethylolpropane Monoallyl Ether by skin penetration for male albino rabbits is greater than 15.8 g/kg.
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