Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 908-552-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- other: Publication
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles. Comparable to guideline study with acceptable restrictions. In the OECD SIDS on sodium carbonate (2002) a similar reliability was assigned
Data source
Reference
- Reference Type:
- publication
- Title:
- Pathologic eefctes in rodents exposed to sodium combustion products
- Author:
- Busch RH, McDonald KE, Briat JK, Morris JE, Graham TM
- Year:
- 1 983
- Bibliographic source:
- Environmental Research, 31, 138-147
Materials and methods
- Principles of method if other than guideline:
- Whole body inhalation to establish LC50
- GLP compliance:
- no
- Test type:
- other:
Test material
- Reference substance name:
- Sodium carbonate
- EC Number:
- 207-838-8
- EC Name:
- Sodium carbonate
- Cas Number:
- 497-19-8
- Molecular formula:
- CH2O3.2Na
- IUPAC Name:
- disodium carbonate
- Test material form:
- aerosol dispenser: not specified
- Remarks:
- migrated information: aerosol
- Details on test material:
- 91% purity sodium carbonate. Impurity 9.0% NaOH
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar and Sprague Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Source - not reported. Age:Adult. Average weight 365g. 6 trials of 10 animals each
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other:
- Details on inhalation exposure:
- Type of exposure: Whole body inhalation to aerosols of sodium combustion products.
- Concentrations: 17 concentrations between 800-4600 mg/m3.
- Particle size: median aerodynamic diameter ± GSD: 1.04±1.97 micrometer
- Type or preparation of particles: Sodium combines with oxygen to form combustion products. These react subsequently and rapidly with atmospheric components. In a typical atmosphere the predominant reactions proceed rapidly from the oxide forms to NaOH, then to Na2CO3. They all form in the atmosphere without appreciable settling and produce an aerosol in the order of 1 micrometre aerodynamic equivalent diameter. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 2 h
- Concentrations:
- 800-4600 mg/m3
- No. of animals per sex per dose:
- 60
- Control animals:
- not specified
- Details on study design:
- DEVIATIONS FROM OECD GUIDELINE 403: 2h exposure instead of 4h exposure; only males used; reporting less elaborate and complete; assays of cellular immunity were included.
- Statistics:
- Not reported
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2 300 mg/m³ air
- Exp. duration:
- 2 h
- Mortality:
- Time of death: During and within 1-2 hr after exposure, or beginning at 1 day after exposure, peaking at 5-7 days, and continuing to 9-10 days after exposure. Number of deaths at each dose were not reported.
- Clinical signs:
- other: Signs of respiratory impairment immediately after exposure. Dyspnea, wheezing, excessive salivation, and distention of the abdomen. In many animals, excessive salivation and repeated swallowing continued during the first 2 hr following exposure. Signs sub
- Gross pathology:
- Lesions in respiratory tract in animals that died limited to the posterior pharynx, larynx, anterior trachea, and in approximately 3% of the animals, lungs.
- Other findings:
- POTENTIAL TARGET ORGANS: Respiratory tract.
SEX-SPECIFIC DIFFERENCES: Not relevant.
OTHER OBSERVATIONS: A transitory immunologic repression. This may be, at least in part, contributory to bacteremia.
Applicant's summary and conclusion
- Executive summary:
LC50 of 2300 mg/m3
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.