Registration Dossier
Registration Dossier
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EC number: 250-157-6 | CAS number: 30374-01-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: National Guideline study with acceptable restrictions.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- The procedure recommended in Section 191.12 of the Federal Hazardous Substances Labeling act was used.
- GLP compliance:
- no
Test material
- Reference substance name:
- Isooctyl 3-mercaptopropionate
- EC Number:
- 250-157-6
- EC Name:
- Isooctyl 3-mercaptopropionate
- Cas Number:
- 30374-01-7
- Molecular formula:
- C11H22O2S
- IUPAC Name:
- 2-methylheptyl 3-sulfanylpropanoate
- Details on test material:
- - Name of test material (as cited in study report): Iso-octyl 3-mercaptopropionate
- Analytical purity: no data
- Other: sample number: bl 1409
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- observation period up to 7 days
- Observation period (in vivo):
- 1, 2, 3, 4 and 7 day(s)
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- The eyes were not irrigated following instillation of the sample.
TOOL USED TO ASSESS SCORE: observations were made with the unaided eye as well as facilitated by magnification and ophthalmic fluorescin.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 day
- Score:
- 0.4
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 2 days
- Score:
- 0.4
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 3 days
- Score:
- 0.4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritant / corrosive response data:
- The material tested produced a very mild transient conjunctival irritation in one of six rabbits tested. No corneal or iridal damage was seen at any observation time.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The material tested produced a very mild transient conjunctival irritation in one of six rabbits tested. No corneal or iridal damage was seen at any observation time.
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