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EC number: 201-164-8 | CAS number: 78-98-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 value of the test item in rats is ca. 1380 mg/kg bw (calculated from nominal dose (30% solution) in study report: 5000 mg/kg bw).
An 7h inhalation exposure of rats to an atmosphere enriched with the test item caused no deaths. The LC50 was >13.6 mg/L and was calculated from the net total of 19.1 g test item applied within 1400 L air.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 380 mg/kg bw
Additional information
In an acute oral toxicity study (BASF SE, 1987), groups of young adult rats (5/sex) were given a single oral dose of unchanged test item as a 30% solution at nominal doses of 1500, 948, 645, 300, 139 mg / kg bw, calculated (30%) from the nominal dosages specified in the study report (5000, 3160, 2150, 1000, 464 mg/kg bw). Animals were then observed for 14 days. Oral LD50 combined: ca. 1380 mg/kg bw (calculated from 4600 mg/kg bw, interpolated in study report for both genders). No differences occurred between the sexes. The following treatment related clinical signs were noted: dyspnea, apathy, abnormal position, staggering, atonia, paresis, piloerection, cyanosis, poor general state. Results were supported by a less reliable study (Peters et al., 1978), where an LD50 of 1990 and 1165 mg/kg bw were reported for males and female rats, respectively.
In an acute inhalation toxicity study (BASF SE, 1987), six young adult rats (3/sex) were exposed by inhalation route to an enriched atmosphere of the test item for 7 hours to the whole body at a nominal mean concentration of 13.6 mg/L. The LC50 was calculated from the net total of 19.1 g test item applied within 1400 L air. Animals then were observed for 14 days. No mortality occurred during this assay. The following clinical signs were noted during exposure: eyelid closure, respiratory rate increased, panting, respiratory sounds, reddish discharge from nose; after exposure: respiratory sounds, reddish discharge from nose (tested positive for blood), stilted gait. Nominal LC50 (combined) from raw data > 13.6 mg/L.
Justification for classification or non-classification
The oral administration of the test item as a 30% solution is harmful (EU: R22; CLP acute oral Cat. 4, H302) according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
The test item did not cause deaths after inhalation at the highest dose applicable (calculated air saturation at 13.6 mg/L). A classification for acute inhalation toxicity is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation 1272/2008/EC.
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