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Diss Factsheets
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EC number: 701-374-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The reliability of this study is in question because of the likely potential that daphnia were exposed to emulsions/free product given that concentrations were run above the water solubility limit.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EEC C.2, Acute toxicity for Daphnia [Comparable to OECD 202]
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- EC Number:
- 701-374-4
- Cas Number:
- 25550-98-5
- Molecular formula:
- C26H47O3P
- IUPAC Name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- Details on test material:
- - Name of test substance: Irgastab CH 300 (CAS# 25550-98-5)- Commercial, purity: Stated to be ‘within specifications’- Commercial batch no. 09520538 (Test identification code: TK 11211) - Supplier: Ciba-Geigy, Ltd, Basel, Switzerland
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test substance stock solution was test substance (20.1 mg) mixed with water and made up to 1000 mL. Calculated amounts of the stock solution to produce the desired test concentrations were added to the water and were homogeneously distributed.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name:
- Strain: Straus 1820
- Source: Ciba-Giegy ecotoxicology testing facility
- Age at study initiation (mean and range, SD):
- Weight at study initiation (mean and range, SD):
- Length at study initiation (length definition, mean, range and SD):
- Valve height at study initiation, for shell deposition study (mean and range, SD):
- Peripheral shell growth removed prior to test initiation:
- Method of breeding:
- Feeding during test: At each water renewal the Daphnia were fed with a suspension of green algae (Scenedesmus subspicatus) supplemented by a suspension of TETRAMIN-extract.
ACCLIMATION
- Acclimation period:
- Acclimation conditions (same as test or not):
- Type and amount of food:
- Feeding frequency:
- Health during acclimation (any mortality observed):
QUARANTINE (wild caught)
- Duration:
- Health/mortality:
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 240 mg/CaCO3/L
- Test temperature:
- 20 +/- 1oC
- pH:
- The pH values of the water ranged from 8.0 to 8.6 at 0 hours and 7.8 to 7.9 at 48 hours.
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- The nominal test concentrations were 0 (blank control), 0.058, 0.1, 0.18, 0.32, 0.58, and 1.0 mg of test substance/L.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass vessels
- Type: covered with watch glasses
- Material, size, headspace, fill volume: 100 mL of solution.
- Aeration: aerated with clean air for at least 24 hours prior to use
- Renewal rate of test solution/water: water partially renewed three times per week
- No. of organisms per vessel: There were a total number of 20 Daphnia per treatment group/4 replicates of 5 Daphnia each.
- No. of vessels per concentration (replicates): 4 replicates of 5 Daphnia each.
- No. of vessels per control (replicates): 4 replicates of 5 Daphnia each.
OTHER TEST CONDITIONS
- Photoperiod: 16 hours/day
- Light intensity: fluorescent lighting
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.6 mg/L
- Basis for effect:
- mobility
- Remarks on result:
- other: 0.4-1.2 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.2 mg/L
- Basis for effect:
- mobility
- Remarks on result:
- other: 0.1-0.4 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- < 0.04 µg/L
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 0.83 mg/L
- Basis for effect:
- mobility
- Dose descriptor:
- NOEC
- Effect conc.:
- < 0.04 mg/L
- Basis for effect:
- mobility
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.04 mg/L
- Basis for effect:
- mobility
- Details on results:
- Immobilization was recorded after 24 and 48 hours of exposure. The EC-50 values were calculated according to method described by Berkson (1953; JASA 48:569-599), and the EC-values were graphically determined on gausso-logarithmic probability paper.
Any other information on results incl. tables
The following are the percent of the immoblizedDaphnia(n = 20 per test concentration) after 24 and 48 hours for each test group:
24 Hours 48 Hours
Test Concentration Total No. (%) Total No. (%)
Blank 0 (0) 0 (0)
0.04 mg/L 1 (5) 5 (25)
0.17 mg/L 1 (5) 8 (40)
0.38 mg/L 2 (10) 7 (35)
0.45 mg/L 9 (45) 18 (90)
0.83 mg/L 15 (75) 19 (95)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- The 48-hr EC50 value was determined to be 0.2 mg/L based on immobility, though test results cannot be used reliably.
- Executive summary:
The 48-hr EC50 value was determined to be 0.2 mg/L based on immobility, though test results cannot be used reliably.
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