Registration Dossier
Registration Dossier
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EC number: 245-152-0 | CAS number: 22673-19-4
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Annex XI section 2 of the Regulation EC 1907/2006, testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance.
The following statement was included in a physico-chemical properties study by Walker & White (2010) concerning the feasibility of a biotic degradation study on the test substance:
"No determination was possible according to Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004, for the following reason:
• During preliminary investigations for the water solubility test, it was concluded that the test item hydrolyses immediately upon contact with water. Substances which hydrolyse rapidly in contact with water are not suitable for determination using Method 111."
The following study was provided in support of omitting the test.
Yoder, R. (2003) Electrospray Ionization Mass Spectrometric Study of Dioctyltin Compounds in Solution.
The study was performed to a good standard, and assigned a reliability score of 2. Electrospray ionization mass spectrometry (ESI/MS) was used to determine whether dioctyltin compounds in water behave like dibutyltin compounds and form oxides relatively quickly The results of the test confirmed this theory. During the study, the test solutions were analysed immediately after the addition of, the analyses provided an indication of the speed of hydrolysis. In all samples hydrolysis products were observed under very short times. In particular, at 125 ng/ml (as Sn), almost the entire parent compound has converted to the oxide in less than 10 minutes (estimated).
Key value for chemical safety assessment
Additional information
Yoder (2003) was provided in support of omitting testing for this endpoint. The study was performed to a good scientific standard with a good level of reporting and was accordingly assigneed a reliability score of 2. The study demonstrated that hydrolysis is extremely rapid. The study was provided for information purposes only, the purpose of the study was to determine experimentally whether dioctyltins behave hydrolytically similarly to dibutyltin compounds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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