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Diss Factsheets
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EC number: 240-385-4 | CAS number: 16294-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Remarks:
- acute
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1970
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: early study; non-GLP; poor sample characterisation, short report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Animals were treated once by intrapertoneal injection. Thereafter they were exposed to UV radiation for twice 6 hours with an interval of 18 hours. An observation period of 7 days followed. A second group was treated in the same way but not exposed to UV-radiation.
- GLP compliance:
- no
- Remarks:
- predates GLP regulation
- Limit test:
- no
Test material
- Reference substance name:
- Fluoreszenzrot GG
- IUPAC Name:
- Fluoreszenzrot GG
- Details on test material:
- no data provided
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: sesame oil
- Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- single injection
Doses / concentrations
- Remarks:
- Doses / Concentrations:
15000 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, sham-exposed
Examinations
- Observations and clinical examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: No data - Sacrifice and pathology:
- no data
- Cell viabilities:
- not applicable
- Humoral immunity examinations:
- not applicable
- Specific cell-mediated immunity:
- not applicable
- Non-specific cell-mediated immunity:
- not applicable
- Other functional activity assays:
- no data
- Other examinations:
- no data
- Positive control:
- no
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Gross pathological findings:
- not specified
Specific immunotoxic examinations
- Cell viabilities:
- not specified
- Humoral immunity examinations:
- not specified
- Specific cell-mediated immunity:
- not specified
- Non-specific cell-mediated immunity:
- not specified
- Other functional activity assays:
- not specified
- Other findings:
- no effects observed
Effect levels
- Dose descriptor:
- NOAEL
- Remarks:
- light sensitisation of the skin
- Effect level:
- 15 000 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
Applicant's summary and conclusion
- Conclusions:
- There was no indication of a light sensitising effect of the test material
- Executive summary:
Five femal mice per group were treated once by intrapertoneal injection at a dose of 15000 mg/kg bw. Immediately thereafter they were exposed to intense UV radiation for twice 6 hours with an interval of 18 hours. An observation period of 7 days followed.
A second group was treated in the same way but not exposed to UV-radiation.
The treatment did not produce any indication of a light sensitising effect of the test material.
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