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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 240-385-4 | CAS number: 16294-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study; Standard and non Standard test method, poor reporting and characterisation of test sample
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Remarks:
- Barail Test using injection
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 5 animals employed
- Principles of method if other than guideline:
- Skin was shaved at the flanks of rabbits. 0.2 ml of a solution of the test material in sesame oil were injected intracutaneously at concentrations of 10, 5, 1, 0.1, 0.01, and 0.001 %. The pure vehicle served as a control.
In a second part of the study 0.5 ml of the highest concentrations (5 & 10 %) were applied epidermally on the intact skin and evaluated visually. This treatment was repeated on 5 consecutive days. - GLP compliance:
- no
- Remarks:
- pre-dates GLP regulations
Test material
- Reference substance name:
- Fluoreszenzrot GG
- IUPAC Name:
- Fluoreszenzrot GG
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Yellow-Silver
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: individual cages
- Diet (e.g. ad libitum): Altromin ad lib.
- Water (e.g. ad libitum): no data
- Acclimation period: no dat
ENVIRONMENTAL CONDITIONS: no data
Test system
- Type of coverage:
- other: Part 1: injection; Part 2: open
- Preparation of test site:
- shaved
- Vehicle:
- other: sesame oil
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 ml
- Concentration (if solution): 0 - 0.001- 0.01 -0.1- 1- 5-10 %
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.2 ml - Duration of treatment / exposure:
- no data
- Observation period:
- no data
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- other: visual inspection and expert judgment
- Basis:
- mean
- Time point:
- other: no data
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No scores were reported
- Irritant / corrosive response data:
- Injection of 5 and 10 % induced erythema of the skin. Epidermal treatment caused no effects.
- Other effects:
- no
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test material did no cause adverse reactions after epidermal application to the intact shaved skin of 5 rabbits.
- Executive summary:
Five daily epidermal applications of 5 and 10 % solutions of the test material in sesame oil to the shaved skin of rabbits caused no adverse reactions.
Intradermal injection of the test material into the shaved skin of rabbits at 0.001 to 10 % in sesame oil caused only mild reactions at 5% and higher.
The test material is considered non irritant after topical application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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