Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 207-563-3 | CAS number: 481-29-8
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Oral Dehydroepiandrosterone for Adrenal Androgen Replacement: Pharmacokinetics and Peripheral Conversion to Androgens and Estrogens in Young Healthy Females after Dexamethasone Suppression
- Author:
- Arit. W et al.
- Year:
- 1 998
- Bibliographic source:
- Journal of Clinical Endocrinology and Metabolism, 83, 6, 1928-1934
- Reference Type:
- publication
- Title:
- Induction of Ovarian Granulosa Cell Tumors in SWXJ-9 Mice with Dehydroepiandrosterone
- Author:
- Beamer WG etl al.
- Year:
- 1 988
- Bibliographic source:
- Cancer Res, 48, 2788-2792
- Reference Type:
- publication
- Title:
- Historic reflection on steroids: Lederle and personal aspects
- Author:
- Bernstein S
- Year:
- 1 992
- Bibliographic source:
- Steroids 57, 392-402
- Reference Type:
- publication
- Title:
- Synthetic Spiro-neurosteroid Analogs Exerting Structure-Specific Neuroprotective Effects
- Author:
- Charalampopoulos I et. al.
- Year:
- 2 008
- Bibliographic source:
- Rev Clin Pharmacol Pharmacokin 22, 119-121
- Reference Type:
- publication
- Title:
- Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease
- Author:
- Gebre-Medhin G et. al.
- Year:
- 2 000
- Bibliographic source:
- Clinical Endocrinology, 52, 775-780
- Reference Type:
- publication
- Title:
- Virilization of the External Genitalia of the Female Rat Fetus by Dehydroepiandrosterone
- Author:
- Goldmann AS
- Year:
- 1 970
- Bibliographic source:
- Endocrinology, 87, 432-435
- Reference Type:
- publication
- Title:
- Effects of dehydroepiandrosterone on oleic acid accumulation in rat liver
- Author:
- Imai K et. al.
- Year:
- 2 003
- Bibliographic source:
- Biochemical Pharmacology, 65, 1583–1591
- Reference Type:
- publication
- Title:
- Effects of Dehydroepiandrosterone (DHEA) on Ubiquinone and Catalase in the Livers of Male F-344 Rats
- Author:
- Khan SA
- Year:
- 2 005
- Bibliographic source:
- Biol. Pharm. Bull., 28(7), 1301—1303
- Reference Type:
- publication
- Title:
- Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity
- Author:
- Kirkland D et. al.
- Year:
- 2 005
- Bibliographic source:
- Mutation Research 584, 1–256
- Reference Type:
- publication
- Title:
- Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?
- Author:
- Laube B et. al.
- Year:
- 2 002
- Bibliographic source:
- TRENDS in Pharmacological Sciences Vol.23 No.11, 519-527
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Prasterone
- EC Number:
- 200-175-5
- EC Name:
- Prasterone
- Cas Number:
- 53-43-0
- IUPAC Name:
- 3-hydroxyandrost-5-en-17-one
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- On the base of the available data on the similar substance "Prasterone", it can be assumed that the substance "3-β-hydroxy-5-α-androstan-17-one"may damage fertility or the unborn child and may cause harm to breast-fed children.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
