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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 207-563-3 | CAS number: 481-29-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Oral Dehydroepiandrosterone for Adrenal Androgen Replacement: Pharmacokinetics and Peripheral Conversion to Androgens and Estrogens in Young Healthy Females after Dexamethasone Suppression
- Author:
- Arit. W et al.
- Year:
- 1 998
- Bibliographic source:
- Journal of Clinical Endocrinology and Metabolism, 83, 6, 1928-1934
- Reference Type:
- publication
- Title:
- Induction of Ovarian Granulosa Cell Tumors in SWXJ-9 Mice with Dehydroepiandrosterone
- Author:
- Beamer WG etl al.
- Year:
- 1 988
- Bibliographic source:
- Cancer Res, 48, 2788-2792
- Reference Type:
- publication
- Title:
- Historic reflection on steroids: Lederle and personal aspects
- Author:
- Bernstein S
- Year:
- 1 992
- Bibliographic source:
- Steroids 57, 392-402
- Reference Type:
- publication
- Title:
- Synthetic Spiro-neurosteroid Analogs Exerting Structure-Specific Neuroprotective Effects
- Author:
- Charalampopoulos I et. al.
- Year:
- 2 008
- Bibliographic source:
- Rev Clin Pharmacol Pharmacokin 22, 119-121
- Reference Type:
- publication
- Title:
- Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease
- Author:
- Gebre-Medhin G et. al.
- Year:
- 2 000
- Bibliographic source:
- Clinical Endocrinology, 52, 775-780
- Reference Type:
- publication
- Title:
- Virilization of the External Genitalia of the Female Rat Fetus by Dehydroepiandrosterone
- Author:
- Goldmann AS
- Year:
- 1 970
- Bibliographic source:
- Endocrinology, 87, 432-435
- Reference Type:
- publication
- Title:
- Effects of dehydroepiandrosterone on oleic acid accumulation in rat liver
- Author:
- Imai K et. al.
- Year:
- 2 003
- Bibliographic source:
- Biochemical Pharmacology, 65, 1583–1591
- Reference Type:
- publication
- Title:
- Effects of Dehydroepiandrosterone (DHEA) on Ubiquinone and Catalase in the Livers of Male F-344 Rats
- Author:
- Khan SA
- Year:
- 2 005
- Bibliographic source:
- Biol. Pharm. Bull., 28(7), 1301—1303
- Reference Type:
- publication
- Title:
- Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity
- Author:
- Kirkland D et. al.
- Year:
- 2 005
- Bibliographic source:
- Mutation Research 584, 1–256
- Reference Type:
- publication
- Title:
- Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?
- Author:
- Laube B et. al.
- Year:
- 2 002
- Bibliographic source:
- TRENDS in Pharmacological Sciences Vol.23 No.11, 519-527
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Prasterone
- EC Number:
- 200-175-5
- EC Name:
- Prasterone
- Cas Number:
- 53-43-0
- IUPAC Name:
- 3-hydroxyandrost-5-en-17-one
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- On the base of the available data on the similar substance "Prasterone", it can be assumed that the substance "3-β-hydroxy-5-α-androstan-17-one"may damage fertility or the unborn child and may cause harm to breast-fed children.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.