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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-01-16 - 2006-07-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
isopropyl (diaminophosphoryl) carbamate
Cas Number:
298692-41-8
Molecular formula:
C4H12N3O3P
IUPAC Name:
isopropyl (diaminophosphoryl) carbamate
Details on test material:
- Analytical purity: > 99%
- Lot/batch No.: S-6

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h
Remarks on exposure duration:
NOT_SPECIFIED
Post exposure observation period:
no post exposure observation

Test conditions

Hardness:
CaCO3 = 236 ppm
Test temperature:
21-22 °C
pH:
7.8 - 7.9
Dissolved oxygen:
at least 8.8 mg/l
Nominal and measured concentrations:
nominal (mg/l)
0.2
0.4
0.8
1.6
3.2
6.4
measured (48h, mg/l):
0.2
0.4
0.8
1.6
3.2
6.4
Reference substance (positive control):
yes
Remarks:
potassium chromate

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 6 400 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC100
Effect conc.:
> 6 400 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
800 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
4 900 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC0
Effect conc.:
200 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
24 h
Dose descriptor:
EC0
Effect conc.:
400 µg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Results with reference substance (positive control):
EC50(24h) = 1.7 mg/l

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The acute toxicity of the test item to Daphnia magna was tested according to the OECD guideline 202. The Daphnia test resulted in the following toxicity values:
EC0 (24 h): 0.4 mg/l
EC50 (24 h): 4.9 mg/l
EC100 (24 h): > 6.4 mg/l
EC0 (48 h): 0.2 mg/l
EC50 (48 h): 0.8 mg/l
EC100 (48 h): > 6.4 mg/l
Executive summary:

The acute toxicity of the test item to Daphnia magna was tested according to the OECD guideline 202. The Daphnia test resulted in the following toxicity values:

EC0 (24 h): 0.4 mg/l

EC50 (24 h): 4.9 mg/l

EC100 (24 h): > 6.4 mg/l

EC0 (48 h): 0.2 mg/l

EC50 (48 h): 0.8 mg/l

EC100 (48 h): > 6.4 mg/l